Abstract： Objective： To observe the clinical effect of Shugan Jieyu Capsules combined with Escitalopram Oxalate on mild to moderate unipolar depression and its effects on the levels of noradrenaline (NE) and 5-hydroxytryptamine (5-HT) in serum and neurological function. Methods：A total of 120 cases of patients with mild to moderate unipolar depression were selected as the study objects，and were divided into the study group and the control group according to the random number table method，with 60 cases in each group. The control group was given the oral administration of Escitalopram Oxalate， and the study group was additionally given the oral administration of Shugan Jieyu Capsules based on the treatment of the control group. Both groups were treated for eight weeks. The clinical effects in the two groups were evaluated； the National Institutes of Health Stroke Scale (NIHSS) scores and the levels of NE， 5-HT， interleukin-1β (IL-1β)，tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in serum were compared before and after treatment between the two groups； the incidence of adverse reactions was observed. Results： There was no significant difference being found in the comparison of the total effective rates between the two groups (P＞0.05). After treatment，the levels of NE and 5-HT in serum in the two groups were increased when compared with those before treatment (P＜0.05)，and the levels of NE and 5-HT in serum in the study group were higher than those in the control group (P＜0.05). After treatment， NIHSS scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the NIHSS score in the study group was lower than that in the control group (P＜0.05). After treatment， the levels of IL-1β，TNF-α and IL-6 in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and levels of IL-1β，TNF-α and IL-6 in serum in the study group were lower than those in the control group (P＜0.05). The incidence of adverse reactions in the study group was lower than that in the control group (P＜0.05). Conclusion： Shugan Jieyu Capsules combined with Escitalopram Oxalate for mild to moderate unipolar depression can effectively improve the levels of NE and 5-HT in serum，reduce the expressions of inflammatory factors，and improve neurological function.