Abstract：Objective：To observe the clinical effect of Jinlianhua Granules combined with Budesonide on acute pharyngitis and its effect on levels of inflammatory factors in serum. Methods：A total of 90 cases of patients with acute pharyngitis were given retrospective analysis and divided into the control group and the observation group according to their different treatment methods， with 45 cases in each group. The control group was treated with Budesonide Suspension for Inhalation， and the observation group was additionally treated with Jinlianhua Granules based on the treatment of the control group. The traditional Chinese medicine (TCM) syndrome scores and levels of inflammatory factors in serum [C- reactive protein (CRP)，interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) ] before and after treatment，as well as the clinical effects，relief time of symptoms，and incidence of adverse reactions were compared between the two groups. Results：The total effective rate was 91.11% in the observation group and 82.22% in the control group， the difference being significant (P＜0.05). Before treatment， there was no significant difference being found in the comparison of TCM syndrome scores including pharyngalgia， dryness and scorching of the pharynx， mucous hyperemia， fever， mild aversion to cold， and cough and yellow sputum between the two groups (P＞0.05)；after treatment，the above TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the scores in the observation group were lower than those in the control group (P＜0.05). The relief time of symptoms including pharyngalgia，dryness and scorching of the pharynx in the observation group was shorter than that in the control group，the difference being significant (P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of IL-6，hs-CRP and TNF-α in serum between the two groups (P＞0.05)； after treatment， the above levels of inflammatory factors in the two groups were decreased when compared with those before treatment (P＜0.05)，and the ３ indexes in the observation group were lower than those in the control group (P＜0.05). The incidence of adverse reactions was 8.88% in the observation group and 17.77% in the control group， the difference being significant (P＜0.05). Conclusion： Jinlianhua Granules combined with Budesonide can improve curative effect for acute pharyngitis， effectively inhibit inflammatory responses in the body， reduce TCM syndrome scores and incidence of adverse reactions，and accelerate the rehabilitation of the disease with high safety.