Abstract： Objective： To observe the clinical effect of acupuncture and moxibustion combined with Escitalopram Oxalate for post- stroke depression. Methods： A total of 70 cases of patients with poststroke depression were divided into the treatment group and the control group according to the random number table method， with 35 cases in each group. The control group was treated with Escitalopram Oxalate，and the treatment group was additionally treated with acupuncture and moxibustion based on the treatment of the control group. Before and after treatment， the relevant indexes of brain injury including S100β protein and myelin basic protein (MBP) were detected in the two groups. The Hamilton Depression Scale (HAMD- 17) was applied to evaluate depression status，Mini- Mental State Examination (MMSE) to detect cognitive dysfunction， National Institute of Health Stroke Scale (NIHSS) to assess neurological deficits， and Functional Independence Measure (FIM) to evaluate activities of daily living. The curative effects and the incidence of adverse reactions were recorded. Results：The total effective rate was 94.29% in the treatment group and 74.29% in the control group，the difference being significant (P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of S100β and MBP between the two groups (P＞0.05). After treatment，the levels of S100β and MBP in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of S100β and MBP in the treatment group were lower than those in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of scores of HAMD，MMSE，NIHSS and FIM between the two groups (P＞0.05). After treatment， the scores of HAMD and NIHSS in the two groups were decreased when compared with those before treatment (P＜0.05)，and the scores of MMSE and FIM were increased when compared with those before treatment (P＜0.05)；the improvement of the above scores in the treatment group was more significant than that in the control group (P＜0.05). During treatment， the incidence of adverse reactions was 5.71% in the treatment group and 14.29% in the control group，there being no significant difference between the two groups (P＞0.05). Conclusion：The therapy of acupuncture and moxibustion combined with Escitalopram Oxalate has a significant effect on post- stroke depression， which can effectively improve the relevant indexes of neurological injury， depression and cognitive dysfunction， promote the recovery of their neurological functions， and improve their activities of daily living，with relatively few adverse reactions.