Abstract： Objective： To observe the clinical effect of Liujun Qutan Jiedu Decoction combined with chemotherapy for non- small cell lung cancer (NSCLC) and its effect on vascular endothelial growth factor (VEGF). Methods：A total of 70 cases of NSCLC patients were randomly divided into the control group and the observation group， with 35 cases in each group. The control group was treated with Gemcitabine Hydrochloride and Cisplatin for injection， and the observation group was additionally treated with Liujun Qutan Jiedu Decoction based on the treatment of the control group. Both groups were treated for 2 courses， with 3 weeks being a course. The changes in Karnofsky Performance Status (KPS) scores and VEGF levels before and after treatment， the clinical effects and the incidence of adverse reactions were compared between the two groups. Results： The total effective rate was 80.00% in the observation group and 57.14% in the control group， the difference being significant (P＜0.05). Before treatment， there was no significant difference being found in the comparison of KPS scores between the two groups (P＞0.05). After treatment，KPS scores in the two groups were significantly increased when compared with those before treatment (P＜0.05)，and KPS score in the observation group was significantly higher than that in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of serum VEGF between the two groups (P＞0.05). After treatment，VEGF level in the observation group was decreased when compared with that before treatment and that in the control group (P＜0.05)； there was no significant difference being found in the comparison of VEGF levels before and after treatment in the control group (P＞0.05). During the treatment，the incidences of decreased white blood cell counts， decreased platelet counts， gastrointestinal reactions and anemia were 20.00% ， 5.71% ， 20.00% and 14.29% respectively in the observation group and were 34.29%，22.86%，40.00% and 34.29% respectively in the control group，differences being significant (P＜0.05)；the incidence of liver and kidney dysfunction was 11.43% in the observation group and 14.29% in the control group，there being no significant difference between the two groups (P＞0.05). Conclusion： Liujun Qutan Jiedu Decoction combined with chemotherapy for NSCLC can enhance the clinical effect， effectively down- regulate the levels of serum VEGF，improve the quality of life of patients，and reduce the incidence of adverse reactions.