Abstract： Objective： To observe the clinical effect of Compound Yuxingcao Mixture combined with Cefixime Capsules for acute pharyngitis with wind- heat syndrome. Methods： A total of 88 cases of patients with acute pharyngitis with wind-heat syndrome were selected and divided into the control group and the observation group according to the random number table method，with 44 cases in each group. The control group was treated with Cefixime Capsules，and the observation group was additionally treated with Compound Yuxingcao Mixture based on the treatment of the control group. Both groups were treated for 5 days. Traditional Chinese medicine (TCM) syndrome scores and the levels of inflammatory indexes in serum before and after treatment， clinical effects， the disappearance time of symptoms， and the incidence of adverse reactions were compared between the two groups. Results：After a 5-day treatment， the total effective rate of clinical effects was 95.45% in the observation group，higher than that of 81.82% in the control group (P＜0.05). The scores of pharyngeal pain， dryness and burning sensation in the pharynx， dysphagia， fever， aversion to cold， and thirst in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above 6 TCM syndrome scores in the observation group were lower than those in the control group (P＜0.05). The disappearance time of pharyngeal pain， redness and swelling of pharynx mucosa， and burning sensation in the pharynx in the observation group were shorter than those in the control group (P＜0.05). The levels of interleukin-6 (IL-6)， C- reactive protein (CRP)，interleukin- 1β (IL- 1β)，and tumor necrosis factor- α (TNF- α) in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of the above 4 inflammatory indexes in serum in the observation group were lower than those in the control group (P＜0.05). During treatment， the incidence of adverse reactions was 11.36% in the observation group， and 6.82% in the control group， there being no significance in the difference (P＞0.05). Conclusion： Compound Yuxingcao Mixture combined with Cefixime Capsules for acute pharyngitis with wind- heat syndrome can enhance clinical effects， improve clinical symptoms of patients， and inhibit inflammatory responses，with safety and reliability.