升阳养血汤联合普拉洛芬滴眼液治疗干眼症临床研究
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R276.7

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Clinical Study on Shengyang Yangxue Tang Combined with Pranoprofen Eye Drops for Xerophthalmia
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    摘要:

    目的:观察升阳养血汤联合普拉洛芬滴眼液治疗干眼症的临床疗效及作用机制。方法:将60 例干眼症患者随机分为对照组与观察组各30 例,对照组使用普拉洛芬滴眼液治疗,观察组采用升阳养血汤联合普拉洛芬滴眼液治疗。比较2 组临床疗效,并比较2 组治疗前后泪膜破裂时间、泪液湿润长度及泪液肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、基质金属蛋白酶-9(MMP-9)、白细胞介素-1β(IL-1β) 水平;评估2 组治疗前后眼睛异物感、干涩、疲劳感、烧灼感和畏光等症状评分。结果:观察组治疗总有效率96.67%,高于对照组73.33%。与同组治疗前比较,治疗后2 组泪膜破裂时间、泪液湿润长度明显延长(P<0.05);与对照组治疗后比较,观察组泪膜破裂时间、泪液湿润长度明显较长(P<0.05)。与同组治疗前比较,治疗后2 组泪液中TNF-α、IL-1、MMP-9、IL-1β 水平均降低(P<0.05);与对照组治疗后比较,观察组治疗后泪液中TNF-α、IL-1、MMP-9、IL-1β 水平均较低(P<0.05)。与同组治疗前比较,治疗后2 组眼睛异物感、干涩、疲劳感、烧灼感、畏光等症状评分均降低(P<0.05);与对照组治疗后比较,观察组治疗后眼睛异物感、干涩、疲劳感、烧灼感、畏光等症状评分均较低(P<0.05)。结论:升阳养血汤联合普拉洛芬滴眼液治疗干眼症患者疗效显著,其机制可能与降低泪液中TNF-α、IL-1、MMP-9、IL-1β 表达水平有关。

    Abstract:

    Abstract: Objective: To observe the clinical effect and mechanism of the therapy of Shengyang Yangxue Tang combined with Pranoprofen Eye Drops on xerophthalmia. Methods: A total of 60 patients with xerophthalmia were randomly divided into the control group and the observation group,with 30 cases in each group. The control group was treated with Pranoprofen Eye Drops,and the observation group was treated with Shengyang Yangxue Tang combined with pranoprofen eye drops. The clinical effects were compared between the two groups. Before and after treatment,the time of tear film,wetting length of tears and the levels of necrosis factor-α(TNF-α),interleukin-1(IL-1),matrix metalloproteinase-9 (MMP-9) and interleukin- 1β(IL- 1β) in tears were compared between the two groups;before and after treatment, the symptom scores of foreign body sensation,dry eyes,asthenopia,burning sensation and photophobia in the two groups were evaluated. Results: After treatment, the total effective rate was 96.67% in the observation group,higher than that of 73.33% in the control group. After treatment,the time of tear film and wetting length of tears in the two groups were significantly longer than those in the same group before treatment(P<0.05); after treatment, the time of tear film and wetting length of tears in the observation group were significantly longer than those in the control group(P<0.05). After treatment, the levels of TNF- α,IL-1,MMP-9 and IL-1β in tears in the two groups were decreased when compared with those before treatment(P<0.05); after treatment, the above four levels in the observation group were lower than those in the control group(P<0.05). After treatment,the symptom scores of foreign body sensation, dry eyes, asthenopia, burning sensation and photophobia in the two groups were decreased when compared with those before treatment(P<0.05);after treatment,the above five scores in the observation group were lower than those in the control group(P<0.05). Conclusion:The therapy of Shengyang Yangxue Tang combined with Pranoprofen Eye Drops has a significant curative effect on patients with xerophthalmia, and its mechanism may be related to reduction on the expression levels of TNF- α, IL-1, MMP-9 and IL-1β in tears.

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胡海慈,张合瑜,郭建立,罗国新,刘浩爽.升阳养血汤联合普拉洛芬滴眼液治疗干眼症临床研究[J].新中医,2022,54(21):139-143

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  • 在线发布日期: 2022-11-15
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