Abstract：Objective：To observe the clinical effect of Jianpi Liqi Tang combined with western medicine therapy for functional dyspepsia(FD) of spleen deficiency and qi stagnation type. Methods ： A total of 240 cases of FD patients were randomly divided into the western medicine group and the Chinese and western medicine group， with 120 cases in each group. The western medicine group was treated with Mosapride Tablets and Rabeprazole Sodium Enteric- coated Tablets， and the Chinese and western medicine group was additionally treated with Jianpi Liqi Tang based on the treatment of the western medicine group. Both groups were treated for eight weeks. The changes in traditional Chinese medicine (TCM) syndrome scores and indexes of gastrointestinal hormones in serum before and after treatment and the clinical effects after treatment in the two groups were evaluated. Results：After treatment，the total clinical effective rate was 94.17% in the Chinese and western medicine group higher than that of 86.67% in the western medicine group(P＜0.05). After treatment， the TCM syndrome scores including epigastric pain， belching and hiccup， gastric fullness and poor appetite in the two groups were decreased when compared with those before treatment(P＜0.05)； the above TCM syndrome scores in the Chinese and western medicine group were lower than those in the western medicine group(P＜0.05). After treatment， the levels of motilin(MTL) and gastrin(GAS) in serum in the two groups were increased when compared with those before treatment(P＜0.05)， and the levels of vasoactive intestinal peptide(VIP) were decreased(P＜ 0.05)；the levels of MTL and GAS in serum in the Chinese and western medicine group were higher than those in the western medicine group(P＜0.05)，and the VIP level was lower(P＜0.05). Conclusion：Jianpi Liqi Tang combined with western medicine therapy has a definite curative effect in treating FD patients of spleen deficiency and qi stagnation type， which can significantly improve clinical symptoms and regulate the secretion of gastrointestinal hormones.