目的：观察血塞通颗粒联合常规西药治疗急性脑梗死（ACI） 的临床疗效。方法：选取ACI 患者100 例，按随机数字表法分为观察组和对照组各50 例。2 组均给予常规西医对症治疗，对照组在常规治疗基础上静脉滴注依达拉奉注射液，观察组在对照组基础上给予血塞通颗粒口服，2 组均治疗14 d。评价2 组临床疗效，比较2 组治疗前后中医证候积分、神经功能缺损程度及实验室指标。结果：观察组总有效率为92.00%，高于对照组76.00%（P＜0.05）。2 组治疗后中医证候积分、美国国立卫生研究院卒中量表（NIHSS） 评分低于治疗前（P＜0.05）；观察组中医证候积分、NIHSS 评分低于对照组（P＜0.05）。2 组治疗后血清肿瘤坏死因子-α （TNF-α）、超敏C-反应蛋白（hs-CRP）、同型半胱氨酸（Hcy） 及神经元特异性烯醇化酶（NSE） 水平低于治疗前（P＜0.05）；观察组治疗后血清TNF-α、hs-CRP、Hcy 及NSE 水平低于对照组（P＜0.05）。结论：血塞通颗粒联合西医对症治疗ACI 疗效显著，可有效缓解患者临床症状，改善神经功能缺损程度，减轻机体炎症反应，降低Hcy 及NSE 水平，从而控制病情发展。
Abstract： Objective： To observe the clinical effect of the therapy of Xuesaitong Granules combined with routine western medicine for acute cerebral infarction(ACI). Methods：A total of 100 cases of patients with ACI were divided into the observation group and the control group according to the random number table method，with 50 cases in each group. Both groups were treated with routine symptomatic treatment of western medicine. The control group was additionally treated with intravenous infusion of Edaravone Injection based on routine treatment，and the observation group was additionally treated with Xuesaitong Granules orally based on the treatment of the control group. Both groups were treated for 14 days. The clinical effects in the two groups was evaluated. Before and after treatment， the Chinese medicine syndrome scores，degree of neurological deficit and laboratory indexes were compared between the two groups. Results：The total effective rate was 92.00% in the observation group，higher than that of 76.00% in the control group(P＜0.05). The Chinese medicine syndrome scores and scores of National Institutes of Health Stroke Scale(NIHSS) in the two groups were lower than those before treatment(P＜0.05)；the above two scores in the observation group were lower than those in the control group(P＜0.05). After treatment， the levels of serum tumor necrosis factor- α(TNF- α)， high- sensitivity C- reactive protein(hs- CRP)， homocysteine(Hcy) and neuron- specific enolase(NSE) were lower than those before treatment(P＜0.05)； after treatment，the above four levels in the observation group were lower than those in the control group (P＜0.05). Conclusion： The therapy of Xuesaitong Granules combined with symptomatic treatment of western medicine has a significant curative effect on ACI， which can effectively relieve the clinical symptoms of patients，improve the degree of neurological deficit，alleviate the inflammatory responses of the body，and reduce the levels of Hcy and NSE，so as to control the development of disease.