目的：观察白虎加桂枝汤联合依托考昔治疗急性痛风性关节炎患者的临床疗效及对炎性因子的影响。方法：将80 例急性痛风性关节炎患者随机分为对照组与观察组各40 例。对照组接受依托考昔治疗，观察组在对照组基础上联合白虎加桂枝汤治疗，比较2 组治疗前后症状积分、血尿酸（UA）、红细胞沉降率（ESR）、肿瘤坏死因子-α（TNF-α） 水平的变化，并比较2 组临床疗效。结果：与同组治疗前比较，治疗后2 组关节疼痛、关节红肿及关节活动受限等症状积分均降低（P＜0.05）；与对照组治疗后比较，观察组治疗后以上各症状积分均较低（P＜0.05）。与同组治疗前比较，治疗后2 组血清UA、ESR 及TNF-α 水平均降低（P＜0.05）；与对照组治疗后比较，观察组治疗后血清UA、ESR 及TNF-α 水平均较低（P＜0.05）。治疗后，观察组治疗总有效率95.00%，高于对照组80.00%（P＜0.05）。结论：白虎加桂枝汤联合依托考昔治疗急性痛风性关节炎可有效控制症状，抑制炎症反应，提高临床疗效。
Abstract：Objective：To observe the curative effect of Baihu and Guizhi Tang combined with etoricoxib for patients with acute gouty arthritis and its effect on inflammatory factors. Methods：A total of 80 cases of patients with acute gouty arthritis were randomly divided into the control group and the observation group， with 40 cases in each group. The control group was treated with etoricoxib，and the observation group was additionally treated with Baihu and Guizhi Tang based on the treatment of the control group. The changes in symptom scores and levels of uric acid(UA)， erythrocyte sedimentation rate(ESR) and tumor necrosis factor- α(TNF- α) in the two groups were compared before and after treatment. The clinical effects in the two groups were compared. Results： After treatment， the symptom scores including joint pain， joint swelling and limited joint movement in the two groups were decreased when compared with those before treatment(P＜0.05)； the above symptom scores in the observation group were lower than those in the control group(P＜0.05). After treatment， the levels of UA， ESR and TNF- α in serum in the two groups were decreased when compared with those before treatment(P＜0.05)；the levels of UA，ESR and TNF-α in serum in the observation group were lower than those in the control group(P＜0.05). After treatment，the total effective rate was 95.00% in the observation group，higher than that of 80.00% in the control group (P＜0.05). Conclusion： Baihu and Guizhi Tang combined with etoricoxib for patients with acute gouty arthritis exert effects by effectively controling symptoms，relieving inflammatory responses and improving clinical efficacy.