参松养心胶囊联合美托洛尔治疗老年慢性心力衰竭伴心律失常临床研究
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Clinical Study on Shensong Yangxin Capsules Combined with Metoprolol for Senile Patients with Chronic Heart Failure Complicated with Arrhythmia
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    摘要:

    目的:观察参松养心胶囊联合美托洛尔治疗老年慢性心力衰竭(CHF) 伴心律失常的疗效及对心率变异性的影响。方法:选取84 例老年CHF 伴心律失常患者,按数字奇偶法分为治疗组及对照组各42 例。2 组均给予常规对症处理,在此基础上,对照组给予美托洛尔治疗,治疗组在对照组基础上给予参松养心胶囊联合治疗。2 组均以4 周为1 个疗程,共治疗3 个疗程。比较2 组临床疗效,比较2 组治疗前后心功能[左室射血分数(LVEF)、左室舒张末期内径(LVEDD)]、心率变异性[R-R 间期均值标准差(SDANN)、R-R 间期总体标准差(SDNN)] 及血清N 末端B 型利钠肽前体(NT-pro BNP)、C-反应蛋白(CRP) 指标值的变化。结果:治疗组临床疗效总有效率为95.24%,对照组为80.95%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组LVEF 指标值均较治疗前升高,LVEDD 指标值均较治疗前下降,差异均有统计学意义(P<0.05);治疗后,治疗组LVEF 指标值高于对照组,LVEDD 指标值低于对照组,差异均有统计学意义(P<0.05)。治疗后,2 组SDNN、SDANN 水平均较治疗前升高,治疗组上述2 项水平均高于对照组,差异均有统计学意义(P<0.05)。治疗后,2 组血清NT-pro BNP、CRP 水平均较治疗前下降,治疗组上述2 项水平均低于对照组,差异均有统计学意义(P<0.05)。结论:参松养心胶囊联合美托洛尔治疗老年CHF 伴心律失常疗效确切,能够改善心功能,延缓心衰,减弱心率变异性,控制病情发展。

    Abstract:

    Abstract: Objective: To observe the curative effect of Shensong Yangxin capsules combined with metoprolol for senile patients with chronic heart failure(CHF) complicated with arrhythmia and its effect on heart rate variability. Methods:A total of 84 cases of senile patients with CHF complicated with arrhythmia were selected and divided into the treatment group and the control group according to the numerical oddeven method,with 42 cases in each group. Both groups were given routine symptomatic treatment;the control group was additionally treated with metoprolol, and the treatment group was additionally treated with Shensong Yangxin capsules combined with metoprolol based on the treatment of the control group. Both groups were treated for three courses,with four weeks being a course. The clinical effects in the two groups were compared;the changes in heart function including left ventricular ejection fraction(LVEF) and left ventricular end-diastolic diameter(LVEDD),heart rate variability including the standard deviation of the averages of normal- to- normal(SDANN) of R- R interval and the standard deviation of normal- to- normal (SDNN) of R- R interval,and the values of N- terminal pro- brain natriuretic peptide(NT- pro BNP) and Creactive protein(CRP) in serum before and after treatment in the two groups were compared. Results:The total effective rate of clinical effect was 95.24% in the treatment group and 80.95% in the control group, the difference being significant(P<0.05). After treatment, the values of LVEF in the two groups were increased when compared with those before treatment,and LVEDD values were decreased,differences being significant(P<0.05). After treatment,the LVEF value in the treatment group was higher than that in the control group, and the LVEDD value was lower, differences being significant(P<0.05). After treatment,the levels of SDNN and SDANN in the two groups were increased when compared with those before treatment,and the levels of SDNN and SDANN in the treatment group were higher than those in the control group,differences being significant(P<0.05). After treatment,the levels of NT-pro BNP and CRP in serum in the two groups were decreased when compared with those before treatment,and the above two levels in the treatment group were lower than those in the control group,differences being significant (P<0.05). Conclusion: The therapy of Shensong Yangxin capsules combined with metoprolol for senile patients with CHF complicated with arrhythmia has a definite curative effect, which can improve heart function,postpone heart failure,reduce heart rate variability and control the development of the disease.

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金小璐,葛晓平,徐玲玲,赵剑锋.参松养心胶囊联合美托洛尔治疗老年慢性心力衰竭伴心律失常临床研究[J].新中医,2022,54(19):75-79

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  • 在线发布日期: 2022-10-08
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