Abstract： Objective： To observe the clinical effect of Juhong capsules combined with Asmeton for acute attack of chronic bronchitis and its effect on prealbumin(PA) and C- reactive protein(CRP) in serum. Methods：A total of 67 cases of patients with acute attack of chronic bronchitis were selected as the study objects and divided into the experiment group and the control group according to different treatment methods，with 37 and 30 cases in each group respectively. Both groups were given basic treatment；the control group was additionally treated with compound methoxyphenamine capsules(Asmeton)， and the experiment group was additionally treated with Juhong capsules based on the treatment of the control group. Clinical effects and the incidence of adverse reactions in the two groups were observed. Scores of main symptoms and signs and levels of PA and CRP in serum in the two groups before and after treatment were compared. Results：The total effective rate was 97.30% in the experiment group，and 76.67% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of scores of main symptoms including cough， expectoration， panting， and the color and feature of phlegm between the two groups(P＞0.05)； after treatment， the above scores in the two groups were decreased when compared with those before treatment(P＜0.05)， and each score in the experiment group was lower than that in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of scores of minor symptoms including distention and fullness in the chest and hypochondrium，fever，and chest X-ray between the two groups(P＞0.05)； after treatment， the above three scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and each score in the experiment group was lower than that in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of PA and CRP in serum between the two groups(P＞0.05)；after treatment，the PA levels in the two groups were increased when compared with those before treatment(P＜0.05)，CRP levels were decreased(P＜0.05)， and the improvement of the two levels in the experiment group was more significant than that in the control group(P＜0.05). The incidence of adverse reactions was 2.70% in the experiment group， and 20.00% in the control group， there being significance in the difference(P＜0.05). Conclusion： Juhong capsules combined with Asmeton has a significant difference in the treatment of patients with acute attack of chronic bronchitis. It can effectively improve PA level in serum，reduce CRP level，and improve clinical symptoms with few adverse reactions.