Abstract： Objective： To observe the effect of Xiaochaihu tang combined with routine therapy on immune function and quality of life of patients with primary liver cancer after transcatheter arterial chemoembolization(TACE). Methods：A total of 82 cases of patients with primary liver cancer were selected as the study subjects， all of whom were given TACE treatment. After operation， the control group was given routine therapy and symptomatic treatment including preventing vomiting，and the observation group was additionally given Xiaochaihu tang based on the treatment of control group. Before and after treatment， the changes in the levels of T lymphocytes including CD3+，CD4+，CD8+ and CD4+/CD8+，immunoglobulin including IgG，IgA and IgM and Quality of Life Questionnaire-Core 30(QOL-C30) scores in the two groups were compared. Results： After treatment， there was no significant difference being found in the comparison of CD3+，CD4+，CD8+ and CD4+/CD8+ in serum before and after treatment in the observation group(P＞0.05). After treatment，CD3+，CD4+ and CD4+/CD8+ in serum in the control group were decreased when compared with those before treatment，and lower than those in the observation group，differences being significant(P＜0.05). After treatment， the levels of IgG， IgM and IgA in serum in the two groups were decreased when compared with those before treatment，and there was significant difference being found in the control group(P＜0.05). After treatment，the levels of the above three items in the observation group were higher than those in the control group， the difference being significant(P＜0.05). After treatment， the scores of physical function， psychological function， material life and social function in QOL-C30 scale in the observation group were increased when compared with those before treatment，and higher than those in the control group，differences being significant(P＜0.05). After treatment，there was no significant change in the scores of the above indexes in the control group， there being no significant difference(P＞0.05). Conclusion：Xiaochaihu tang combined with routine therapy for patients with primary liver cancer after TACE can effectively protect their immune function and improve the quality of life .