栀子金花丸辅助西药治疗复发性口腔溃疡临床研究
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R988.2

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Clinical Study on Zhizi Jinhua Pills Assisting Western Medicine for Recurrent Oral Ulcer
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    摘要:

    目的:观察栀子金花丸辅助西药治疗复发性口腔溃疡的临床疗效及对免疫功能的影响。方法:回顾性选取98 例复发性口腔溃疡患者,根据资料中治疗方式将其分为对照组和观察组各49 例。对照组给予地塞米松片、复合维生素B 片和维生素C 片口服,观察组在对照组基础上加用栀子金花丸口服。评价2 组临床疗效,比较2 组溃疡疼痛缓解时间、溃疡愈合时间、不良反应、复发率和治疗前后中医证候评分、疼痛视觉模拟评分(VAS)、免疫功能。结果:观察组总有效率为89.80%,高于对照组79.59%,差异有统计学意义(P<0.05)。治疗后,2 组各项症状评分均降低,且观察组低于对照组(P<0.05)。观察组溃疡疼痛缓解时间、溃疡愈合时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,2 组CD3+、CD4+、NK 较治疗前上升,CD8+较治疗前下降(P<0.05);且观察组CD3+、CD4+、NK 高于对照组,CD8+低于对照组(P<0.05)。治疗后,2 组VAS 评分较治疗前降低,且观察组低于对照组(P<0.05)。观察组不良反应发生率为6.12%,低于对照组18.37%,差异有统计学意义(P<0.05)。观察组治疗后6 个月、1 年随访复发率均低于对照组(P<0.05)。结论:栀子金花丸辅助西药治疗复发性口腔溃疡可提高临床疗效,降低中医证候评分和不良反应,缩短溃疡面愈合时间,减轻疼痛,提高免疫功能,且安全性高,复发率低。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Zhizi Jinhua pills assisting western medicine for recurrent oral ulcer and its effects on immune function. Methods: A total of 98 cases of patients with recurrent oral ulcer were selected retrospectively and divided into the control group and the observation group according to different treatment methods in data, with 49 cases in each group. The control group was given the oral administration of dexamethasone tablets, vitamin B complex tablets and vitamin C tablets,and the observation group was additionally treated with Zhizi Jinhua pills based on the treatment of the control group. Clinical effects in the two groups were evaluated. Chinese medicine syndrome scores, Visual Analogue Scale(VAS) for pain and immune function before and after treatment as well as the ulcer pain relief time,ulcer healing time,adverse reactions and recurrence rates were compared between the two groups. Results: The total effective rate was 89.80% in the observation group, higher than that of 79.59% in the control group,the difference being significant(P<0.05). After treatment,the scores of each syndrome in the two groups were decreased, and the scores in the observation group were lower than those in the control group(P<0.05). The ulcer pain relief time and ulcer healing time in the observation group were shorter than those in the control group, the difference being significant(P<0.05). After treatment, CD3+,CD4+,and NK in the two groups were increased when compared with those before treatment,and CD8+ were decreased(P<0.05);CD3+,CD4+,and NK in the observation group were higher than those in the control group, and CD8 + was lower(P<0.05). After treatment, VAS scores in the two groups were decreased when compared with those before treatment,and the score in the observation group was lower than that in the control group(P<0.05). The incidence of adverse reactions was 6.12% in the observation group, lower than that of 18.37% in the control group, the difference being significant(P<0.05). The recurrence rates in the observation group after six months and one year of treatment were lower than those in the control group(P<0.05). Conclusion: Zhizi Jinhua pills assisting western medicine for recurrent oral ulcer can enhance clinical effect, reduce Chinese medicine syndrome scores and adverse reactions, shorten ulcer healing time, relieve pain, and improve immune function, with high safety and low recurrence rate.

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贾可盼,王可,江晶莹.栀子金花丸辅助西药治疗复发性口腔溃疡临床研究[J].新中医,2022,54(13):134-138

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  • 在线发布日期: 2022-07-07
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