麝香保心丸联合西药治疗冠心病临床研究
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R541.4

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Clinical Study on Shexiang Baoxin Pills Combined with Western Medicine for Coronary Heart Disease
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    摘要:

    目的:观察麝香保心丸联合西药治疗冠心病的临床疗效。方法:选取176 例冠心病患者,随机分成观察组和对照组各88 例。对照组给予阿司匹林肠溶片、硫酸氢氯吡格雷片治疗,观察组在对照组基础上加服麝香保心丸治疗,2 组均治疗3 个月。比较2 组临床疗效及心肌梗死发生率,比较2 组治疗前后氧化应激指标及肝、肾功能指标。结果:观察组总有效率97.7%,高于对照组87.5% (P<0.05)。观察组心肌梗死发生率4.5%,低于对照组14.8% (P<0.05)。治疗后,2 组超氧化物歧化酶(SOD) 水平均较治疗前升高(P<0.05),丙二醛(MDA) 水平均较治疗前降低(P<0.05);观察组SOD 水平高于对照组(P<0.05),MDA 水平低于对照组(P<0.05)。治疗后,2 组谷丙转氨酶(ALT)、谷草转氨酶(AST)、尿素氮(BUN)、肌酐(Cr) 水平与同组治疗前比较,以及上述指标组间比较,差异均无统计学意义(P>0.05)。结论:麝香保心丸联合西药治疗冠心病疗效确切,能够有效改善患者的氧化应激指标,降低心肌梗死发生率,且安全性高。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Shexiang Baoxin pills combined with western medicine for coronary heart disease. Methods: A total of 176 cases of patients with coronary heart disease were selected and divided into the observation group and the control group randomly,with 88 cases in each group. The control group was treated with aspirin enteric- coated tablets and clopidogrel bisulfate tablets , and the observation group was additionally treated with Shexiang Baoxin pills based on the treatment of the control group. Both groups were treated for three months. The clinical effects and the incidences of myocardial infarction in the two groups were compared;the indexes of oxidative stress,liver function and kidney function before and after treatment in the two groups were compared. Results:The total effective rate was 97.7% in the observation group,higher than that of 87.5% in the control group(P<0.05). The incidence of myocardial infarction was 4.5% in the observation group,lower than that of 14.8% in the control group(P<0.05). After treatment,the levels of superoxide dismutase(SOD) were increased when compared with those before treatment, and the levels of malondialdehyde(MDA) were decreased(P<0.05);the SOD level in the observation group was higher than that in the control group(P<0.05), and the MDA level was lower(P<0.05). In the comparison of the levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST),blood urea nitrogen(BUN) and creatinine(Cr) in the two groups before and after treatment as well as the comparison of the above indexes between the two groups,there was no significance in the difference(P>0.05). Conclusion:The therapy of Shexiang Baoxin pills combined with western medicine for coronary heart disease has a definite curative effect,which can effectively improve the oxidative stress indexes of patients and reduce the incidence of myocardial infarction with high safety.

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陈国英,周晓峰.麝香保心丸联合西药治疗冠心病临床研究[J].新中医,2022,54(10):78-80

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  • 在线发布日期: 2022-05-24
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