Abstract： Objective： To observe the clinical effect of the therapy of modified Liujunzi tang on elderly patients with obstructive sleep apnea hypopnea syndrome(OSAHS) and its effect on oxidative stress and inflammatory responses. Methods：A total of 96 elderly patients with OSAHS were randomly divided into the control group and the observation group， with 48 cases in each group. The control group was intervened with routine lifestyle， and the observation group was additionally treated with modified Liujunzi tang based on the treatment of the control group. The clinical effects， Chinese medicine syndrome scores， scores of Epworth Sleepiness Scale(ESS)， levels of oxidative stress， including superoxide dismutase(SOD) and malondialdehyde(MDA)， levels of inflammatory indexes， including tumor necrosis factor- α(TNF- α)， interleukin- 6(IL- 6) and C-reactive protein(CRP)，and adverse reactions were compared between the two groups. Results： The total effective rate was 93.75% in the observation group and 77.08% in the control group，the difference being significant (P＜0.05). Before treatment，there was no significant difference being found in the comparison of scores of Chinese medicine syndrome and ESS between the two groups(P＞0.05)； after treatment， the above two scores in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the above two scores in the observation group were significantly lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of SOD and MDA between the two groups(P＜0.05). After treatment，SOD levels in the two groups were significantly increased when compared with those before treatment(P＜0.05)， MDA levels were significantly decreased(P＜0.05)；the SOD level in the observation group was significantly higher than that in the control group (P＜0.05)， and MDA level was significantly lower(P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of TNF- α，IL-6 and CRP between the two groups(P＞0.05)；after treatment，the above levels in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the above levels in the observation group were lower than those in the control group(P＜0.05). Conclusion： The therapy of modified Liujunzi tang based on the routine lifestyle intervention has a good curative effect on elderly patients with OSAHS，which can improve the Chinese medicine syndromes and somnolence of patients and reduce the levels of oxidative stress and inflammation in the body.