骨肽注射液与丹红注射液联合治疗骨质疏松性骨折术后临床研究
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R580;R687.3

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Clinical Study on Combined Application of Ossotide Injection Combined with Dan⁃ hong Injection for Patients After Osteoporotic Fracture Surgery
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    摘要:

    目的:观察骨质疏松性骨折患者术后联合应用骨肽注射液与丹红注射液的临床疗效。方法:选取128 例骨质疏松性骨折患者,按随机数字表法分为对照组与观察组各64 例。2 组均行手术治疗,对照组采取常规药物治疗,观察组在对照组基础上予以骨肽注射液及丹红注射液治疗。比较2 组临床疗效,比较2 组治疗前后骨代谢[血清Ⅰ型胶原羧基端交联肽(CTX-1)、骨碱性磷酸酶(BALP)、骨钙素(BGP)]及凝血功能[凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)]水平的变化,观察2 组治疗期间不良反应发生率。结果:观察组临床疗效总有效率为90.63%,对照组临床疗效总有效率为75.00%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组CTX-1 水平均较治疗前下降,BALP、BGP 水平均较治疗前上升,差异均有统计学意义(P<0.05);治疗后,观察组CTX-1 水平低于对照组,BALP、BGP 水平均高于对照组,差异均有统计学意义(P<0.05)。治疗后,2 组TT、PT、APTT 水平均较治疗前升高,观察组上述3 项水平均高于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为9.38%,对照组不良反应发生率为10.94%,2 组比较,差异无统计学意义(P>0.05)。结论:骨肽注射液联合丹红注射液应用于骨质疏松性骨折疗效较好,可有效改善机体骨代谢及凝血功能,促进骨折愈合,且用药安全性较高。

    Abstract:

    Abstract:Objective:To observe the clinical effect of combined application of ossotide injection combined with Danhong injection for patients after osteoporotic fracture surgery. Methods:A total of 128 cases of patients with osteoporotic fracture were selected and divided into the control group and the observation group according to the random number table method, with 64 cases in each group. Both groups were given surgery. The control group was treated with routine medicine,and the observation group was additionally treated with ossotide injection combined with Danhong injection based on the treatment of the control group. Clinical effects were compared between the two groups. Before and after treatment, changes in bone metabolism [serum type I carboxy-terminal collagen crosslinks(CTX-1),bone alkaline phosphatase(BALP),bone gla protein (BGP)] and coagulation function [thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT)] were compared between the two groups. Incidences of adverse reactions during treatment were observed in the two groups. Results:The total clinical effective rate was 90.63% in the observation group and 75.00% in the control group,the difference being significant(P<0.05). After treatment, CTX- 1 levels in the two groups were decreased when compared with those before treatment, and levels of BALP and BGP were increased, differences being significant(P<0.05). After treatment, CTX- 1 level in the observation group was lower than that in the control group,and levels of BALP and BGP were higher, differences being significant(P<0.05). After treatment,levels of TT,PT and APTT in the two groups were increased when compared with those before treatment,and the above three levels in the observation group were higher than those in the control group,differences being significant(P<0.05). The incidence of adverse reactions was 9.38% in the observation group and 10.94% in the control group, there being no significance in the difference(P<0.05). Conclusion: Ossotide injection combined with Danhong injection has a good curative effect in the treatment of osteoporotic fracture,which can effectively improve bone metabolism and coagulation function,and promote the healing from fracture,with relatively high safety.

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李建娣,沈志华.骨肽注射液与丹红注射液联合治疗骨质疏松性骨折术后临床研究[J].新中医,2022,54(7):115-119

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  • 在线发布日期: 2022-04-12
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