利舒康胶囊对维持性血液透析患者炎症反应及氧化应激的影响
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R692.5

基金项目:


Effect of Lishukang Capsules on Inflammatory Response and Oxidative Stress in Patients with Maintenance Hemodialysis
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:观察利舒康胶囊对维持性血液透析(MHD) 患者炎症反应及氧化应激的影响。方法:选取140 例MHD 患者,按随机数字表法分为对照组和观察组,每组70 例。对照组给予常规对症治疗,观察组在对照组基础上加用利舒康胶囊治疗,2 组均治疗6 个月。比较2 组临床疗效及并发症发生率;比较2 组治疗前后中医证候评分及白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)、丙二醛(MDA)、同型半胱氨酸(Hcy)、超氧化物歧化酶(SOD) 水平。结果:观察组总有效率为88.57%,高于对照组的75.71%(P<0.05)。观察组并发症发生率为30.00%,低于对照组的48.57%(P<0.05)。治疗后,2 组中医证候评分及IL-6、TNF-α、CRP、MDA、Hcy 水平均较治疗前降低(P<0.05),SOD 水平均较治疗前升高(P<0.05);观察组中医证候评分及IL-6、TNF-α、CRP、MDA、Hcy 水平均低于对照组(P<0.05),SOD 水平高于对照组(P<0.05)。结论:利舒康胶囊治疗MHD 患者可提高临床疗效,有效缓解其临床症状,减轻机体炎症反应,调节氧化应激状态,降低并发症发生率。

    Abstract:

    Objective: To observe the effect of Lishukang capsules on inflammatory response and oxidative stress in patients with maintenance hemodialysis(MHD). Methods:A total of 140 cases of MHD patients were selected and divided into the control group and the observation group according to the random number table method,with 70 cases in each group. The control group was given routine symptomatic treatment, and the observation group was additionally treated with Lishukang capsules based on the treatment of the control group. Both groups were treated for six months. The clinical effects and the incidences of complications in the two groups were compared. Before and after treatment, Chinese medicine syndrome score and the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP), malonaldehyde(MDA),homocysteine(Hcy) and superoxide dismutase(SOD) in the two groups were compared. Results:The total effective rate was 88.57% in the observation group, higher than that of 75.71% in the control group(P<0.05). The incidence of complications was 30.00% in the observation group,lower than that of 48.57% in the control group(P<0.05). After treatment,Chinese medicine syndrome scores and the levels of IL-6,TNF-α,CRP,MDA and Hcy in the two groups were decreased when compared with those before treatment(P<0.05),and SOD levels were increased(P<0.05);Chinese medicine syndrome score and the levels of IL- 6,TNF- α,CRP,MDA and Hcy in the observation group were lower than those in the control group(P<0.05),and SOD level was higher(P<0.05). Conclusion:Lishukang capsules for MHD patients can improve the clinical effect,effectively relieve the clinical symptoms of patients and the inflammatory responses,regulate the oxidative stress state,and reduce the incidence of complications.

    参考文献
    相似文献
    引证文献
引用本文

蒋旭华.利舒康胶囊对维持性血液透析患者炎症反应及氧化应激的影响[J].新中医,2022,54(2):78-82

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2022-01-22
  • 出版日期: