益肾养阴活血通络方治疗糖尿病肾病临床研究
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R692;R587.2

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Clinical Study on Yishen Yangyin Huoxue Tongluo Prescription for Diabetic Nephropathy
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    摘要:

    目的:观察益肾养阴活血通络方治疗糖尿病肾病的临床疗效。方法:将收治的符合纳入标准的112 例糖尿病肾病患者作为临床研究对象,按随机数字表法将所有患者分为2 组各56 例。2 组均给予基础治疗,对照组在基础治疗上给予盐酸贝那普利片,研究组在对照组治疗方案的基础上给予益肾养阴活血通络方治疗,2 组均连续治疗后12 周后观察临床疗效,观察比较尿白蛋白排泄率(UAER)、尿β2 微球蛋白(β2-MG)、血管内皮生长因子(VEGF) 及骨形态发生蛋白-7 (BMP-7) 水平。结果:临床疗效总有效率研究组92.86%,高于对照组75.00%,2 组临床总有效率比较,差异有统计学意义(P<0.05)。治疗后,2 组UAER、β2-MG、VEGF 水平均较治疗前下降,且研究组低于对照组,差异均有统计学意义(P<0.05)。2 组BMP-7 水平均较治疗前上升,且研究组高于对照组,差异均有统计学意义(P<0.05)。结论:益肾养阴活血通络方治疗糖尿病肾病的临床效果良好,可降低UAER 及β2-MG,改善患者细胞因子表达。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Yishen Yangyin Huoxue Tongluo prescription on diabetic nephropathy. Methods:A total of 112 cases of patients with diabetic nephropathy who met the inclusion criteria were treated as clinical research objects and divided into two groups according to the random number table method,with 56 cases in each group. Both groups were given basic treatment; the control group was additionally treated with benazepril hydrochloride tablets,and the study group group was additionally treated with Yishen Yangyin Huoxue Tongluo prescription based on the treatment of the control group. After 12-week treatment,clinical effects were observed in the two groups;levels of urinary albumin excretion rate(UAER), urinary β2- microglobulin(β2- MG), vascular endothelial growth factor(VEGF) and bone morphogenic protein-7(BMP-7) were observed and compared between the two groups. Results:The total clinical effective rate was 92.86% in the study group,higher than that of 75.00% in the control group,the difference being significant(P< 0.05). After treatment,levels of UAER,β2- MG and VEGF in the two groups were decreased when compared with those before treatment,and the levels in the study group were lower than those in the control group,differences being significant (P<0.05). Levels of BMP-7 in the two groups were increased when compared with those before treatment,and the level in the study group was higher than that in the control group,differences being significant(P<0.05). Conclusion:Yishen Yangyin Huoxue Tongluo prescription has a good clinical effect on diabetic nephropathy,which can reduce UAER and β2- MG,and improve the expression of cytokine.

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梁湛.益肾养阴活血通络方治疗糖尿病肾病临床研究[J].新中医,2022,54(2):67-70

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  • 在线发布日期: 2022-01-22
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