桂枝芍药知母汤联合西药治疗类风湿性关节炎疗效观察及对肢体功能的影响
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R593.22

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Clinical Observation of Guizhi Shaoyao Zhimu Tang Combined with Western Medicine for Rheumatoid Arthritis and Its Effect on Limb Function
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    摘要:

    目的:观察桂枝芍药知母汤联合西药治疗类风湿性关节炎的临床疗效及对肢体功能的影响。方法:选取类风湿性关节炎患者80 例,按随机数字表法分为对照组和研究组各40 例。对照组采用依托考昔片、注射用重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白治疗,研究组在对照组的基础上加用桂枝芍药知母汤治疗。比较2 组临床疗效,比较2 组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)、骨保护素(OPG)、核因子κB 受体活化因子配基(RANKL)、类风湿因子(RF) 水平及Fugl-Meyer 运动功能评估量表(FMAS) 评分。结果:研究组总有效率为95.0%,对照组为82.5%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组TNF-α、IL-6、CRP、RANKL、RF 水平均较治疗前降低(P<0.05),且研究组TNF-α、IL-6、CRP、RANKL、RF 水平低于对照组(P<0.05);2 组OPG 水平均较治疗前升高(P<0.05),且研究组OPG水平高于对照组(P<0.05)。治疗后,2 组上、下肢FMAS 评分均较治疗前升高(P<0.05),且研究组上、下肢FMAS 评分高于对照组(P<0.05)。结论:桂枝芍药知母汤联合西药治疗类风湿性关节炎可提高临床疗效,减轻炎症反应,提高肢体功能,疗效优于单纯西药治疗。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Guizhi Shaoyao Zhimu tang combined with western medicine for rheumatoid arthritis and its effect on limb function. Methods:A total of 80 cases of patients with rheumatoid arthritis were selected and divided into the control group and the study group according to the random number table method,with 40 cases in each group . The control group was treated with etoricoxib tablets and recombinant human type Ⅱtumor necrosis factor receptor-antibody fusion protein for injection,and the study group was additionally treated with Guizhi Shaoyao Zhimu tang based on the treatment of the control group. The clinical effects in the two groups were compared. The levels of tumor necrosis factor- α(TNF- α), interleukin- 6(IL- 6), C- reactive protein(CRP), osteoprotegerin(OPG), receptor activator of nuclear factor κB ligand(RANKL) and rheumatoid factors(RF) as well as the scores of Fugl-Meyer Motor Function Assessment Scale(FMAS) in the two groups were compared. Results:The total effective rate was 95.0% in the study group and 82.5% in the control group,the difference being significant(P<0.05). After treatment,the levels of TNF-α,IL-6,CRP,RANKL and RF in the two groups were decreased when compared with those before treatment(P<0.05), and the above levels in the study group were lower than those in the control group(P<0.05);the levels of OPG in the two groups were increased when compared with those before treatment(P<0.05),and the level of OPG in the study group was higher than that in the control group(P<0.05). After treatment,FMAS scores of upper and lower limbs in the two groups were increased when compared with those before treatment(P<0.05), and the FMAS score of upper and lower limbs in the study group were higher than those in the control group(P<0.05). Conclusion:The therapy of Guizhi Shaoyao Zhimu tang combined with western medicine for rheumatoid arthritis can enhance the clinical effect, relieve inflammatory responses and improve limb function, whose curative effect is better than that of simple western medicine.

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陶江涛,刘方,王欣,高改.桂枝芍药知母汤联合西药治疗类风湿性关节炎疗效观察及对肢体功能的影响[J].新中医,2022,54(2):1-4

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  • 在线发布日期: 2022-01-22
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