Abstract：Objective：To discuss the potential mechanism of Jiaotai Tiaomai prescription treating coronary heart disease based on network pharmacology. Methods：The components and targets of Jiaotai Tiaomai prescription were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)；potential targets in coronary heart disease were obtained by using disease databases which included Online Mendelian Inheritance in Man(OMIM)， GeneCards，Genetic Association Database(GAD)，Therapeutic Target Database(TTD) and DisGeNET；the potential targets of Jiaotai tiaomai prescription in the treatment of coronary heart disease was obtained by taking the intersection. Cytoscape 3.7.2 software was applied to build "prescription- component- target" network. With the help of STRING database and Cytoscape 3.7.2 software，protein interaction analysis was carried out，and key targets and sub modules were screened out. Finally，DAVID database was used for the gene ontology(GO) and Kyoto encyclopedia of genes and genomes(KEGG) pathway enrichment analysis，and Reactome database was used for Reactome enrichment analysis；the map of “drug-componenttarget- pathway” was made. Results：In Jiaotai Tiaomai prescription，there were 405 components and 146 potential targets for coronary heat disease which included 6 sub modules and 10 key targets. The main components of Jiaotai Tiaomai prescription in the treatment of coronary heart disease were quercetin，glycine，β-Sitosterol，(R)-hydrogenated berberine and apigenin. Jiaotai Tiaomai prescription played a therapeutic role by regulating hypoxia inducible factor- 1(HIF- 1) signaling pathway， neuroactive ligand- receptor interaction， cyclic guanosine monophosphate- protein kinase G(cGMP- PKG) signaling pathway， phosphatidylinositol 3 kinase- protein kinase B(PI3K- Akt) signaling pathway and vascular endothelial growth factor(VEGF) signaling pathway. Conclusion：In order to treat coronary heart disease，Jiaotai tiaomai prescription may regulate PI3K- Akt signaling pathway to regulate cardiac remodeling processes such as cardiomyocyte apoptosis and angiogenesis， improve cardiomyocyte hypoxia tolerance， strengthen myocardial protection against myocardial ischemiareperfusion injury，reduce lipid and glucose，and regulate endocrine level.