基于真实世界分析注射用灯盏花素治疗冠心病的临床用药特征
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R541.4

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国家重点研发计划项目(2018YFC1707400)


Clinical Medication Characteristics of Breviscapine Injection for Coronary Heart Disease Based on Real World Study
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    摘要:

    目的:基于真实世界分析注射用灯盏花素治疗冠心病的人群特点及临床用药特征。方法:从医院临床信息系统(HIS) 的数据仓库(EMR) 中,提取应用注射用灯盏花素且第一诊断为冠心病的电子病历,提取并同构数据后,使用SPSS Clementine21.0 进行一般资料、合并用药规则等分析。结果:提取出的9 321 例冠心病患者年龄大多为65~80 岁(45.24%),男性稍多于女性,入院数最多的节气为寒露(5.74%);冠心病患者常合并原发性高血压病(44.12%)、脑梗死(18.14%)、2 型糖尿病(17.70%) 等;中医证型多为气阴两虚证(13.02%)、肝肾亏虚证(12.78%)、痰瘀互结证(11.34%) 等;单次用药剂量超说明书(5~50 mg) 者应用频次为7 991 例次(58.02%)。临床常联用西药为阿司匹林(14.29%)、美托洛尔(6.79%)、氨氯地平(5.24%),常联合的中药为参麦注射液(3.64%)、复方丹参滴丸(3.40%)、速效救心丸(3.30%)。结论:注射用灯盏花素的冠心病患者以老年人群为主,合并症复杂多样,临床使用剂量需加强规范,合并用药与冠心病临床指南以及中医证候相契合,有一定规律可循,可提供临床诊治、优化用药线索。

    Abstract:

    Abstract: Objective: To analyze the population characteristics and clinical medication characteristics of breviscapine injection in the treatment of coronary heart disease(CHD) based on the real world study. Methods: The electronic medical records of breviscapine injection and the first diagnosis of CHD were extracted from the Electronic Medical Record system (EMR) and Hospital Information System(HIS). After extracting and establishing data, SPSS Clementine 21.0 software was used to analyze the general data and the rules of medicine combination. Results: Most of the 9 321 patients with CHD extracted from the systems were aged between 65 and 80 years old(45.24%),with males slightly more than females. The solar term of the year when most patients were admitted into hospital was Cold Dews(5.74%). Patients with CHD were often complicated with essential hypertension(44.12%),cerebral infarction(18.14%),type 2 diabetes mellitus(17.70%),etc. The Chinese medicine syndromes were mainly deficiency of both qi and yin(13.02% ), liver- kidney depletion(12.78% ), and binding of stasis and phlegm(11.34%),etc. The frequency of medicine whose single dose exceeded the instruction 5-50 mg was 7 991 cases(58.02% ). In clinical practice, commonly used western medicines were combined with aspirin(14.29% ), metoprolol(6.79%) and amlodipine(5.24%),and commonly used traditional Chinese medicines were combined with Shenmai injection(3.64%),compound Danshen dropping pills(3.40%) and Suxiao Jiuxin pills(3.30%). Conclusion:The CHD patients treated with breviscapine injection are mainly elderly people with complex and diverse comorbidities,and the clinical use of combined drugs needs to be standardized. The combined use of drugs fits with the clinical guidelines of coronary artery disease as well as Chinese medical evidence,and there is a certain pattern to follow,which can provide clues for clinical diagnosis and treatment and optimization of drug use.

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孙粼希,谢雁鸣,黎元元,杨晓晨.基于真实世界分析注射用灯盏花素治疗冠心病的临床用药特征[J].新中医,2021,53(19):35-40

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  • 在线发布日期: 2021-10-09
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