Abstract： Objective： To observe the clinical effect of salvia ligustrazine injection combined with inosine and sodium chloride injection for coronary heart disease. Methods： A total of 92 cases of patients with coronary heart disease were divided into the control group and the observation group according to the random number table method， 46 cases in each group. Both groups were given routine medicine treatment including β blockers，nitroglycerin and calcium channel blocker； the control group was additionally treated with inosine and sodium chloride injection， and the observation group was additionally treated with salvia ligustrazine injection based on the treatment of the control group. Both groups were treated for 14 days. Before and after treatment，the left ventricular ejection fraction，endothelial function and blood lipid indexes in the two groups were compared. The clinical effect and the incidences of adverse reactions in the two groups were compared. Results：After treatment，the levels of left ventricle ejection fraction，nitric oxide，prostacyclin and high density lipoprotein (HDL) in the two groups were increased when compared with those before treatment(P＜0.05)，and the levels of triglyceride (TG)， total cholesterol(TC) and low density lipoprotein(LDL) were decreased(P＜0.05)； the levels of left ventricle ejection fraction，nitric oxide，prostacyclin and HDL in the observation group were higher than those in the control group(P＜0.05)， and the levels of TG，TC and LDL were lower(P＜0.05). The clinical effect in the observation group was better than that in the control group(Z=1.660，P＜0.05). The incidence of adverse reactions was 13.04% in the observation group and 8.70% in the control group， there being no significance in the difference(P＞0.05). Conclusion： The application of salvia ligustrazine injection combined with inosine and sodium chloride injection for coronary heart disease can improve heart function， endothelial function and blood lipid levels more effectively，with no obvious increase in adverse reactions to medication.