复方活血灵汤防治胫骨平台骨折术后下肢深静脉血栓形成临床研究
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R654.4

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Clinical Study on Compound Huoxueling Tang for Deep Venous Thrombosis of Lower Extremities After Surgery for Tibial Plateau Fracture
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    摘要:

    目的:观察复方活血灵汤联合西医常规预防胫骨平台骨折术后下肢深静脉血栓(DVT) 形成的临床疗效。方法:选取80 例胫骨平台骨折手术患者,随机分为治疗组与对照组各40 例。对照组予以抗凝、抗感染、止痛等西医常规治疗,治疗组在对照组的基础上予以复方活血灵汤治疗,2 组均治疗2 周。分析比较2 组凝血功能、血液流变学、炎症因子、氧化应激水平及DVT 发生率。结果:治疗组无发生DVT 发生,对照组发生DVT 3 例(7.50%),2 组DVT 发生率比较,差异无统计学意义(P> 0.05)。治疗前,2 组凝血功能[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)]、血液流变学[血浆黏度、全血高切黏度、纤维蛋白原(Fib)]、炎症因子[肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)、白细胞介素-8(IL-8)]、氧化应激[超氧化物歧化酶(SOD)、丙二醛(MDA)] 水平比较,差异无统计学意义(P>0.05)。治疗后,2 组PT、APTT、TT 水平均较治疗前增加(P<0.05),且治疗组PT、APTT、TT 高于对照组(P<0.05);2 组血浆黏度、全血高切黏度、Fib 水平均较治疗前下降(P<0.05),且治疗组3 项指标水平均低于对照组(P<0.05);2 组TNF-α、IL-6、IL-8 水平均较治疗前下降(P<0.05),且治疗组TNF-α、IL-6、IL-8 水平低于对照组(P<0.05);2 组SOD 水平均较治疗前上升(P<0.05),MDA 水平均较治疗前下降(P<0.05),且治疗组SOD 水平高于对照组(P<0.05)、MDA 水平低于对照组(P<0.05)。结论:复方活血灵汤联合常规治疗干预胫骨平台骨折术后DVT 形成疗效显著,能够延迟凝血时间,改善血流动力,降低炎症因子氧化应激水平,从而预防血栓形成。

    Abstract:

    Abstract: Objective: To observe the clinical effect of compound Huoxueling tang combined with routine western medicine for preventing deep venous thrombosis(DVT) of lower extremities after surgery for tibial plateau fracture. Methods: A total of 80 cases of patients with tibial plateau fracture were randomly divided into the treatment group and the control group,40 cases in each group. The control group was treated with routine western medicine including anticoagulation,antiinfection and analgesia, and the treatment group was additionally treated with compound Huoxueling tang based on the treatment of the control group. Both groups were treated for two weeks. The levels of coagulation function,hemorheology, inflammatory factors and oxidative stress as well as the incidence of DVT in the two groups were analyzed and compared. Results: No DVT occurred in the treatment group, and three cases(7.50% ) occurred in the control group; there was no significant difference being found in the comparison of the incidence of DVT between the two groups(P>0.05). Before treatment,there was no significant difference being found in the comparison of the levels of coagulation function including prothrombin time(PT),activated partial thromboplastin time(APTT),and thrombin time(TT),hemorheology including plasma viscosity, whole blood high shear viscosity and fibrinogen(Fib), inflammatory factors including tumornecrosis factor- alpha (TNF- α), interleukin- 6(IL- 6) and interleukin- 8(IL- 8), and oxidative stress including superoxide dismutase(SOD) and malondialdehyde(MDA) between the two groups(P>0.05). After treatment, PT, APTT and TT in the two groups were increased when compared with those before treatment(P<0.05),and PT,APTT and TT in the treatment group were higher than those in the control group(P<0.05);the levels of plasma viscosity,whole blood high shear viscosity and FIB in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of the above three indexes in the treatment group were lower than those in the control group(P<0.05);the levels of TNF- α,IL- 6 and IL- 8 in the two groups were decreased when compared with those before treatment(P<0.05),and the levels in the treatment group were lower than those in the control group(P<0.05); SOD levels in the two groups were increased when compared with those before treatment(P<0.05),and MDA levels were decreased(P<0.05);SOD in the treatment group was higher than that in the control group(P<0.05), and MDA was lower(P<0.05). Conclusions: The therapy of compound Huoxueling tang combined with routine treatment has significant curative effect in intervening the formation of DVT after surgery for tibial plateau fracture,which can delay the coagulation time,improve the hemodynamics,and reduce the levels of inflammatory factors and oxidative stress,thus preventing the thrombosis.

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王芝芬.复方活血灵汤防治胫骨平台骨折术后下肢深静脉血栓形成临床研究[J].新中医,2021,53(12):106-110

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  • 在线发布日期: 2021-06-23
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