麝香保心丸联合西药治疗不稳定性心绞痛临床研究
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R541.4

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Clinical Study on Shexiang Baoxin Pills Combined with Western Medicine for Unstable Angina
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    摘要:

    目的:观察麝香保心丸联合西药治疗气虚血瘀型不稳定性心绞痛的疗效。方法:以150 例气虚血瘀型不稳定性心绞痛患者作为研究对象,按照随机数字表法分为对照组和研究组各75 例,2 组均予常规西药治疗,研究组加服麝香保心丸,2 组均连续治疗30 d。于治疗前、治疗30 d 后检测平板试验相关指标,统计心绞痛发作情况和硝酸甘油服药剂量,评价临床疗效,统计治疗期间药物不良反应发生情况。结果:治疗后,2 组ST 段下降0.1 mV 的时间、最大ST 段下降幅度、ST 段下移持续时间、耗氧量和最大负荷心率检测结果均较治疗前改善(P<0.01),研究组以上指标检测结果均优于对照组(P<0.01)。2 组心绞痛发作频率、发作持续时间及硝酸甘油服药剂量均较治疗前减少和缩短(P<0.01),研究组心绞痛发作频率、发作持续时间和硝酸甘油服药剂量均短于或少于对照组(P<0.01)。研究组临床疗效总有效率94.67%,高于对照组的77.33%,差异有统计学意义(P<0.01)。2 组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:在常规西药治疗的基础上加服麝香保心丸可显著改善不稳定性心绞痛患者的心功能,有效缓解心绞痛症状,提高疗效,用药安全性较高。

    Abstract:

    Abstract: Objective: To observe the curative effect of Shexiang Baoxin pills combined with western medicine for unstable angina of qi deficiency and blood stasis type. Methods:A total of 150 cases of patients with unstable angina of qi deficiency and blood stasis type were included as the study subjects and divided into the control group and the study group according to the random number table method, 75 cases in each group. Both groups were treated with routine western medicine, and the study group was additionally treated with Shexiang Baoxin pills. Both groups were treated for 30 days. Before treatment and after 30- day treatment, the related indexes of treadmill test were detected, the attack of angina pectoris and the dosage of nitroglycerin were counted. The clinical effect was evaluated. During treatment,the incidence of adverse reactions was observed. Results: After treatment, the time of decline of 0.1 mV at ST segment, the maximum descent range at ST segment,the duration of ST segment depression,the oxygen consumption and the maximum load of heart rate in the two groups were improved when compared with those before treatment(P<0.01),and the above indexes in the study group were better than those in the control group(P<0.01). The frequency of angina pectoris,the duration of attack and the dosage of nitroglycerin in the two groups were decreased and shortened when compared with those before treatment (P<0.01), the frequency of angina pectoris, the duration of attack and the dosage of nitroglycerin in the study group were shorter or less than those in the control group(P<0.01). The total effective rate was 94.67% in the study group, higher than that of 77.33% in the control group,the difference being significant(P<0.01). There was no significant difference being found in the comparison of the total incidences of adverse reactions between the two groups(P>0.05). Conclusion:On the basis of routine western medicine treatment,the additional treatment of Shexiang Baoxin pills can significantly improve the heart function of patients with unstable angina pectoris,which can effectively relieve the symptoms of angina pectoris, improve the curative effect,with high medication safety.

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陈跃欢.麝香保心丸联合西药治疗不稳定性心绞痛临床研究[J].新中医,2021,53(12):58-61

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  • 在线发布日期: 2021-06-23
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