目的：观察柴胡加龙骨牡蛎汤治疗轻微型肝性脑病（MHE） 的临床效果。方法：选取78 例MHE 患者，随机分为对照组与试验组各39 例，对照组采用乳果糖治疗，试验组给予柴胡加龙骨牡蛎汤联合乳果糖治疗。比较2 组中医证候评分、血氨水平、数字连接试验（NCT） 完成时间、数字符号试验（DST） 评分及生活质量评分。结果：治疗后，2 组中医证候评分均较治疗前降低（P＜0.05），试验组中医证候评分低于对照组（P＜0.05）。治疗后，2 组血氨水平、NCT 完成时间均较治疗前降低（P＜0.05），DST 评分均较治疗前升高（P＜0.05）；试验组血氨水平、NCT 完成时间均低于对照组（P＜0.05），DST 评分高于对照组（P＜0.05）。治疗后，2 组生理健康、理健康、社会关系、周围环境评分均较治疗前升高（P＜0.05）；试验组心理健康、社会关系评分高于对照组（P＜0.05）。结论：柴胡加龙骨牡蛎汤联合乳果糖治疗MHE 疗效确切，可降低血氨水平，提高患者的生活质量。
Abstract： Objective： To observe the effect of Chaihu Plus Longgu Muli tang on patients with minimal hepatic encephalopathy(MHE). Methods：A total of 78 cases of MHE patients were randomly divided into the control group and the experiment group， 39 cases in each group. The control group was treated with lactulose， and the experiment group was additionally treated with Chaihu Plus Longgu Muli tang based on the treatment of the control group. Chinese medicine syndrome scores， levels of blood ammonia as well the completion time of number connection test(NCT)， the scores of digital symbol test(DST) and quality of life in the two groups were compared. Results：After treatment，Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and the score in the experiment group was lower than that in the control group(P＜0.05). After treatment，the levels of blood ammonia and the completion time of NCT in the two groups were decreased when compared with those before treatment(P＜0.05)，and DST scores were increased(P＜0.05)；the level of blood ammonia and the completion time of NCT in the experiment group were lower than those in the control group(P＜0.05)， and the DST score was higher(P＜0.05). After treatment， the scores of physical health，mental health，social relationship and surrounding environment in the two groups were all increased when compared with those before treatment(P＜0.05)；the scores of mental health and social relationship in the experiment group were higher than those in the control group(P＜0.05). Conclusion：The therapy of Chaihu Plus Longgu Muli tang combined with lactulose has definite curative effect in treating MHE，which can reduce the levels of blood ammonia and improve the quality of life of patients.