崔玉衡祛风汤治疗维持性血液透析患者皮肤瘙痒症临床研究
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R692.5;R758.3+1

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河南开封科技攻关项目(1903071) [作者简介] 钱莉莉(1985-),女,医学硕士,


Clinical Study on CUI Yuheng's Qufeng Tang for Cutaneous Pruritus in Patients Under⁃ going Maintenance Hemodialysis
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    摘要:

    目的:观察崔玉衡祛风汤对维持性血透患者皮肤瘙痒症的作用机制,为维持性血液透析患者皮肤瘙痒的治疗提供新途径。方法:选取本院肾病风湿科血液净化中心收治的维持性血液透析皮肤瘙痒症患者120例,随机分为崔玉衡祛风汤组与乌蛇祛风汤组各60例。2组均进行西医常规治疗,崔玉衡祛风汤组加予崔玉衡祛风汤治疗,乌蛇祛风汤组加予乌蛇祛风汤治疗。采用视觉模拟评分(VAS)、行为评分(BRS)、瘙痒情绪评分和皮肤干燥程度评分评价临床疗效,检测患者外周血相关实验指标、白细胞介素-12(IL-12) 含量以及IL-12 mRNA相对表达量。结果:治疗后,VAS评分、BRS评分、瘙痒情绪评分和干燥程度评分分值显著下降(P<0.01);血红蛋白(Hb) 升高(P<0.05),甲状腺旁激素(PTH)、血钙和血磷下降(P<0.05);IL-12mRNA和IL-12表达水平显著上升(P<0.01)。与乌蛇祛风汤组比较,崔玉衡祛风汤组的VAS评分、BRS评分、瘙痒情绪评分和干燥程度评分分值较低(P<0.05),IL-12 mRNA和IL-12表达水平显著上升(P<0.01)。VAS评分、BRS评分、瘙痒情绪评分与IL-12呈负相关(P<0.05)。结论:崔玉衡祛风汤具有止痒功效,治疗维持性血液透析皮肤瘙痒症疗效显著,其机制可能为改善离子平衡和上调IL-12表达介导免疫作用抑制微生物增殖。

    Abstract:

    Abstract: Objective: To observe the mechanism of CUI Yuheng's Qufeng tang on cutaneous pruritus in patients undergoing maintenance hemodialysis,and to provide a new approach for the treatment of the disease. Methods:A total of 120 cases of patients undergoing maintenance hemodialysis with cutaneous pruritus who were admitted and treated in blood purification center of the department of nephropathy and rheumatism in our hospital were selected,and randomly divided into the CUI Yuheng's Qufeng tang group and the Wushe Qufeng tang group,60 cases in each group. Both groups were given routine western medicine treatment; the CUI Yuheng's Qufeng tang group was additionally given CUI Yuheng's Qufeng tang; the Wushe Qufeng tang group was additionally given Wushe Qufeng tang. The clinical effect was evaluated via the scores of Visual Analogue Scale(VAS),Behavior Rating Scale(BRS),the scores of emotion caused by pruritus and the degree of dry skin. The related experimental indexes in the peripheral blood,the contents of interleukin- 12(IL- 12) and the relative expression of IL-12 mRNA were detected. Results:After treatment,in the two groups,the scores of VAS,BRS,emotion caused by pruritus,as well as the degree of dryness were significantly decreased(P<0.01);the levels of Hb were increased (P<0.05), and the levels of PTH, Ca and P in the blood were decreased(P<0.05); the levels of the expression of IL- 12mRNA and IL-12 were significantly increased(P<0.01). Compared with those in the Wushe Qufeng tang group,the scores of VAS,BRS,emotion caused by pruritus,as well as the degree of dryness in the CUI Yuheng's Qufeng tang group were lower(P<0.05),and the levels of the expression of IL-12mRNA and IL-12 were significantly increased(P<0.01). There was a negative correlation between the scores of VAS,BRS,as well as emotion caused by pruritus and the contents of IL-12(P<0.05). Conclusion: CUI Yuheng's Qufeng tang has antipruritic effect and significant curative effect in treating patients undergoing maintenance hemodialysis with cutaneous pruritus. Its mechanism may be the improvement of ion balance and the up-regulation of the expression of IL-12 so as to mediate the immune function and inhibit proliferation of microorganism.

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钱莉莉,陈凯,鲍皓月,沈元丽,邵海英.崔玉衡祛风汤治疗维持性血液透析患者皮肤瘙痒症临床研究[J].新中医,2020,52(11):97-100

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  • 在线发布日期: 2020-06-04
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