| 摘要: |
| 目的：观察通天灸刺联合多巴丝肼片治疗帕金森病（PD） 的临床疗效及对患者血瘀状态的影响。方法：将60 例PD患者随机分为观察组和对照组，每组30 例。对照组给予多巴丝肼片治疗，观察组在对照组基础上加用通天灸刺治疗，2 组均治疗3 个月。检测2 组治疗前后血清脂质过氧化物（LPO）、超氧化物歧化酶（SOD）、白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、纤维蛋白原（FBG）、D-二聚体（D-D）、血小板计数（BPC） 及脑内多巴胺（DA）、5-羟色胺（5-HT） 水平，记录2 组治疗前后血瘀证证候评分，比较2 组治疗前后改良Webster 症状量表评分及临床疗效。结果：治疗后，2 组血清IL-1β、TNF-α、FBG、D-D、BPC 水平及观察组LPO、SOD 水平均较治疗前降低（P＜0.05），观察组上述7 项血清学指标均低于对照组（P＜0.05）。治疗后，观察组脑内DA、5-HT 水平均较治疗前升高，且均高于对照组，差异均有统计学意义（P＜0.05）。对照组脑内DA、5-HT 水平治疗前后比较，差异均无统计学意义（P＞0.05）。治疗后，2 组肢体颤抖、舌象、脉象、唇色、皮下瘀斑、肌肤甲错评分均较治疗前降低（P＜0.05），观察组上述6 项血瘀证证候评分均较对照组降低更明显（P＜0.05）。治疗后，2 组改良Webster 症状量表评分均较治疗前降低（P＜0.05），观察组改良Webster 症状量表评分较对照组降低更明显（P＜0.05）。治疗结束6 个月后随访，观察组改良Webster 症状量表评分低于对照组（P＜0.05）。观察组总有效率为93.3%，高于对照组的76.7%（P＜0.05）。结论：通天灸刺配合多巴丝肼片治疗PD，可以提高临床疗效，改善血瘀状态。 |
| 关键词: 帕金森病 通天灸刺 多巴丝肼片 血瘀 促炎因子 神经递质 脂质过氧化物 超氧化物歧化酶 |
| DOI： |
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| 基金项目:深圳市地方级领军人才项目（20171205285D）；深龙英才项目（2018010513B）；深圳市实用型临床医学人才项目（SY2014013） |
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| Clinical Effect on Tongtian Intradermal Injection Combined with Levodopa andBenserazide Tablets for Parkinson Disease |
| CHEN Youguo,QIU Jinzhu,ZHU Chengxiu,CHEN Jiasun |
| (单篇PDF全文查阅请上中国知网下载阅读（中国知网电子版刊出时间：纸刊刊出日期一个月左右）) |
| Abstract: |
| Abstract： Objective： To observe the clinical effect of tongtian intradermal injection combined with levodopa and
benserazide tablets for Parkinson disease(PD) and its effect on blood stasis. Methods：A total of 60 cases of PD patients were
randomly divided into the observation group and the control group，30 cases in each group. The control group was
given levodopa and benserazide tablets，and the observation group was additionally treated with tongtian intradermal
injection based on the treatment of the control group. Both groups were treated for three months. Before and after
treatment，the levels of lipid peroxide(LPO)，superoxide dismutase(SOD)，interleukin-1β(IL-1β)，tumor necrosis factor-α
(TNF- α ) ， fibrinogen(FBG) ， D- dimer(D- D) and blood platelet count(BPC) in serum ， as well as dopamine(DA) and
5- hydroxytryptamine(5- HT) in the brain were detected in the two groups. The scores of blood stasis syndrome before and
after treatment were recorded in the two groups. The scores of modified Webster Rating Scale before and after treatment，
and the clinical effect after treatment were compared between the two groups. Results：After treatment，the levels of IL-1β，
TNF- α，FBG，D- D and BPC in serum in the two groups，as well as the levels of LPO and SOD in the observation group
were decreased when compared with those before treatment(P＜0.05)；the seven serum indexes above in the observation
group were lower than those in the control group(P＜0.05). After treatment，the levels of DA and 5- HT in the brain in the observation group were increased when compared with those before treatment，higher than those in the control group after
treatment，differences being significant(P＜0.05). In the control group，there was no significance being found in differences
when compared the levels of DA and 5-HT in the brain with those before and after treatment(P＞0.05). After treatment，the
scores of limb shaking，tongue manifestation，pulse condition，lip color，subdermal ecchymosis，and scaly skin in the two
groups were decreased when compared with those before treatment(P＜0.05)，and the decrease in six scores of blood stasis
syndrome above in the observation group were more significant than those in the control group(P＜0.05). After treatment，the
scores of modified Webster Rating Scale in the two groups were decreased when compared with those before treatment(P＜
0.05)，and the decrease in the observation group was more significant than that in the control group(P＜0.05). In the followup
six months after the treatment，the scores of modified Webster Rating Scale in the observation group were lower than
those in the control group(P＜0.05). The total effective rate was 93.3% in the observation group，higher than that of 76.7% in
the control group(P＜0.05). Conclusion：In the treatment of PD，the therapy of tongtian intradermal injection combined with
levodopa and benserazide tablets can improve clinical effect and resolve blood stasis. |
| Key words: Keywords： Parkinson disease Tongtian intradermal injection Benserazide tablets Blood stasis Pro- inflammatory
cytokines Neurotransmitter Lipid peroxide Superoxide dismutase |
