珍黄丸联合替硝唑局部应用治疗智齿冠周炎临床研究
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Clinical Study on Zhenhuang Pills Combined with Tinidazole for Local Treatment of Pericoronitis of Wisdom Tooth
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    摘要:

    目的:观察珍黄丸联合替硝唑局部应用治疗智齿冠周炎的临床疗效。方法:将智齿冠周炎患者140 例随机分为对照组与观察组,每组70 例。对照组采用替硝唑局部应用治疗,观察组采用替硝唑局部应用联合珍黄丸治疗。观察比较2 组治疗前后症状体征积分(牙龈红肿、压痛、张口受限) 情况、炎症消退时间、止痛维持时间及细菌学指标变化情况,评价2 组总体临床疗效。结果:总有效率观察组为94.29%,对照组为81.43%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组患者牙龈红肿、压痛、张口受限等积分均较治疗前明显降低(P<0.05),且观察组各项积分明显低于对照组(P<0.05)。治疗后,观察组炎症消退时间短于对照组,止痛维持时间长于对照组,差异均有统计学意义(P<0.05)。治疗后,2 组患者细菌密度、G-细菌百分比均较治疗前降低(P<0.05),G+细菌百分比较治疗前升高(P<0.05);且观察组各项指标改善较对照组更显著(P<0.05)。结论:与单用替硝唑治疗比较,联合珍黄丸治疗智齿冠周炎疗效显著,可更好地控制急性炎症,改善疼痛、肿胀等临床症状,并能延长止痛时间及抑制口腔细菌生长。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Zhenhuang pills combined with tinidazole for local treatment of pericoronitis of wisdom tooth. Methods:A total of 140 cases of patients with pericoronitis of wisdom tooth were randomly divided into the control group and the observation group,70 cases in each group. The control group was given local treatment of tinidazole,and the observation group was additionally given Zhenhuang pills based on the treatment of the control group. Before and after treatment,the changes in the scores of symptoms and signs including gingival redness,tenderness and limitation of mouth opening,the extinction time of inflammation,the maintenance time of analgesia and the bacteriological indexes in the two groups were observed and compared. The total clinical effect in the two groups was evaluated.Results: The total effective rate was 94.29% in the observation group and 81.43% in the control group,the difference being significant (P<0.05). After treatment, the scores of gingival redness, tenderness and limitation of mouth opening in the two groups were significant decreased when compared with those before treatment(P<0.05),and the scores in the observation group were significantly lower than those in the control group(P<0.05). After treatment,the extinction time of inflammation in the observation group was shorter than that in the control group,and the maintenance time of analgesia was longer,differences being significant(P<0.05). After treatment,the bacterial density and the percentage of G- bacteria in the two groups were decreased when compared with those before treatment(P<0.05), and the percentage of G + bacteria was increased(P< 0.05);the changes in the above indexes in the observation group were more significant than those in the control group(P< 0.05). Conclusion:Compared with that of simple tinidazole,the application of tinidazole combined with Zhenhuang pills has significant curative effect in treating pericoronitis of wisdom tooth, and can better control acute inflammation, improve clinical symptoms such as pain and swelling,maintain analgesic time and inhibit bacterial growth in the oral cavity.

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吕爽,洪皓琦,邵春岚.珍黄丸联合替硝唑局部应用治疗智齿冠周炎临床研究[J].新中医,2020,52(21):75-77

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  • 在线发布日期: 2020-11-05
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