补肾膏方联合阿仑膦酸钠片治疗绝经妇女骨质疏松症肾精不足证临床研究
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R580

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全国第四批中医临床优秀人才研修项目(2017-24号);嘉兴市科技局课题(2018AD32141)


Clinical Study on Bushen Herbal Paste Combined with Alendronate Sodium Tablets for Postmenopausal Osteoporosis with Kidney Essence Insufficiency Syndrome
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    摘要:

    目的:观察补肾膏方联合阿仑膦酸钠片治疗绝经妇女骨质疏松症(PMOP) 肾精不足证的临床疗效。方法:将120 例PMOP 肾精不足证患者随机分为观察组和对照组各60 例。2 组均给予抗骨质疏松基础措施治疗。对照组口服阿仑膦酸钠片,观察组在对照组治疗基础上加服补肾膏方,2 组疗程均为12 个月。检测2 组治疗前后腰椎、股骨粗隆间骨密度,以及骨钙素(OC)、骨碱性磷酸酶(BALP)、Ⅰ型胶原交联羧基末端肽(CTX) 水平;评价2 组治疗前后肾精不足证及视觉模拟评分法(VAS) 评分;评价2 组骨质疏松症疗效及中医证候疗效。结果:观察组骨质疏松症总有效率为96.67%,高于对照组的83.33% (P<0.05)。观察组中医证候疗效总有效率为95.00%,高于对照组的80.00%(P<0.05)。治疗后,2 组腰椎、股骨粗隆间骨密度均增加(P<0.05);观察组腰椎、股骨粗隆间骨密度均大于对照组(P<0.05)。治疗后,2 组OC 水平均升高,BALP、CTX 水平均下降(P<0.05);观察组OC 水平高于对照组,BALP、CTX 水平低于对照组(P<0.05)。治疗后,2 组肾精不足证积分及VAS 评分均下降(P<0.01);观察组肾精不足证积分及VAS 评分均低于对照组(P<0.01)。结论:补肾膏方联合阿仑膦酸钠片治疗PMOP肾精不足证可减轻临床症状,改善骨代谢及骨转换状态,增加骨密度。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Bushen herbal paste combined with alendronate sodium tablets for postmenopausal osteoporosis(PMOP) with kidney essence insufficiency syndrome. Methods:A total of 120 cases of PMOP patients with kidney essence insufficiency syndrome were randomly divided into the observation group and the control group, 60 cases in each group. Both groups were given basic treatment of anti- osteoporosis. The control group was given oral administration of alendronate sodium tablets,and the observation group was additionally given Bushen herbal paste based on the treatment of the control group. Both groups were treated for 12 months. Before and after treatment,lumbar and femoral intertrochanteric bone mineral density as well as the levels of osteocalcin(OC),bone alkaline phosphatase(BALP) and crosslinked carboxyterminal telopeptide of type I collagen(CTX) in the two groups were detected; the scores of kidney essence insufficiency syndrome and Visual Analogue Scale(VAS) in the two groups were evaluated. The curative effect of osteoporosis and Chinese medicine syndromes in the two groups was evaluated. Results: The total effective rate of osteoporosis was 96.67% in the observation group,higher than that of 83.33% in the control group(P<0.05). The total effective rate of Chinese medicine syndromes was 95.00% in the observation group,higher than that of 80.00% in the control group(P<0.05). After treatment,lumbar and femoral intertrochanteric bone mineral density in the two groups was increased when compared with that before treatment(P<0.05),and the above indexes in the observation group were higher than those in the control group (P<0.05). After treatment,OC levels in the two groups were increased,and the levels of BALP and CTX were significantly decreased(P<0.05);OC level in the observation group was higher than that in the control group,and the levels of BALP and CTX were lower(P<0.05). After treatment,the scores of kidney essence insufficiency syndrome and VAS in the two groups were decreased(P<0.01); the scores in the observation group were lower than those in the control group(P<0.01). Conclusion:The therapy of Bushen herbal paste combined with alendronate sodium tablets for PMOP with kidney essence insufficiency syndrome can relieve clinical symptoms, improve bone metabolism and bone turnover, and increase bone mineral density.

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俞琪芳,丁红生,吴潍.补肾膏方联合阿仑膦酸钠片治疗绝经妇女骨质疏松症肾精不足证临床研究[J].新中医,2020,52(20):91-94

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  • 在线发布日期: 2020-10-19
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