补肾健脾汤治疗脾肾两虚证精神分裂症临床研究
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R749.3

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Clinical Study on Bushen Jianpi Tang for Schizophrenia with Spleen-Kidney Deficiency Syndrome
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    摘要:

    目的:观察补肾健脾汤治疗脾肾两虚证精神分裂症(SCH) 的临床疗效及其对认知功能的影响。方法:将脾肾两虚证SCH 患者200 例随机分为对照组和观察组,每组100 例。对照组给予阿立哌唑口服,观察组在对照组的基础上给予补肾健脾汤治疗,2 组疗程均为12 周。观察比较2 组治疗前后阳性和阴性症状量表(PANSS) 评分及精神分裂症认知功能成套测验(MCCB) 评分,并统计2 组总体临床疗效及不良反应。结果:总有效率观察组为93.00%,对照组为82.00%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组患者一般精神病理、阴性症状、阳性症状评分均较治疗前明显降低(P<0.05),且观察组各项评分低于对照组(P<0.05)。治疗后观察组连线、迷宫、情绪管理、空间广度、持续操作、数字序列、语言记忆、视觉记忆等评分均较治疗前升高(P<0.05);且患者连线、情绪管理、空间广度、持续操作的评分均高于对照组(P<0.05)。治疗后,对照组仅连线、迷宫、语言记忆评分较治疗前升高(P<0.05)。结论:补肾健脾汤辅助治疗脾肾两虚证SCH 患者,可有效改善患者认知功能,提高临床疗效。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Bushen Jianpi tang for schizophrenia(SCH) with the spleen-kidney deficiency syndrome and its effect on cognitive function. Methods: A total of 200 cases of SCH patients with the spleenkidney deficiency syndrome were randomly divided into the control group and the observation group, 100 cases in each group. The control group was given the oral administration of aripiprazole; the observation group was additionally given Bushen Jianpi tang based on the treatment of the control group. Both groups were treated for 12 weeks. The scores of Positive and Negative Symptom Scale(PANSS) and Matrics Consensus Cognitive Battery(MCCB) before and after treatment were observed and compared between the two groups. The total clinical effect and adverse reactions in the two groups were counted. Results: The total effective rate was 93.00% in the observation group and 82.00% in the control group, the difference being significant(P<0.05). After treatment, the scores of general psychopathology, negative symptoms and positive symptoms in the two groups were significantly decreased when compared with those before treatment(P<0.05), and each score in the observation group was significantly lower than that in the control group(P<0.05). After treatment,the scores of Trail Making Test, mazes subtest, managing emotions branch, spacial span subset, Continuous Performance Test,number sequencing subtest,Hopkins Verbal Learning Test- Revised,and Brief Visual Memory Test- Revised in the observation group were increased when compared with those before treatment(P<0.05);the scores of Trail Making Test, managing emotions branch,spacial span subset,and Continuous Performance Test were higher than those in the control group(P<0.05). After treatment,in the control group,only the scores of Trail Making Test,mazes subtest,and Hopkins Verbal Learning Test- Revised were increased when compared with those before treatment(P<0.05). Conclusion: Bushen Jianpi tang in adjuvant therapy of SCH patients with the spleen- kidney deficiency syndrome,can effectively improve their cognitive function and clinical effect.

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徐莉,夏乐宏,宋清海.补肾健脾汤治疗脾肾两虚证精神分裂症临床研究[J].新中医,2020,52(20):68-70

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  • 在线发布日期: 2020-10-19
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