|目的：观察痛泻要方治疗腹泻型肠易激综合征的临床疗效。方法：选取腹泻型肠易激综合征患者80 例，按随机数字表法分为对照组和观察组各40 例。2 组患者均给予饮食、生活方式等常规指导，对照组给予匹维溴铵片治疗，观察组给予痛泻要方治疗。比较2 组患者的临床疗效，检测血清脑源性神经营养因子（BDNF）、5-羟色胺（5-HT）、酪神经肽（NPY）、白细胞介素-8（IL-8）、白细胞介素-10（IL-10）、干扰素-γ（IFN-γ） 水平变化。结果：观察组总有效率为97.50%，高于对照组85.00%，差异有统计学意义（P＜0.05）。治疗后，2 组腹痛、腹泻次数、大便次数及大便性状症状评分均较治疗前降低，且观察组腹痛、腹泻次数、大便次数及大便性状症状评分低于对照组（P＜0.05）。治疗后，2 组血清BDNF、NPY 水平均较治疗前升高，5-HT 水平较治疗前降低（P＜0.05）；且观察组血清BDNF、NPY 水平高于对照组，5-HT 水平低于对照组（P＜0.05）。治疗后，2 组IL-8、IFN-γ 水平均低于治疗前，且观察组IL-8、IFN-γ 水平低于对照组（P＜0.05）；2 组IL-10 水平较治疗前升高，且观察组IL-10 水平高于对照组（P＜0.05）。结论：痛泻要方可有效缓解腹泻型肠易激综合征患者的临床症状，维持血清中BDNF 水平，抑制炎症反应。
|关键词: 腹泻型肠易激综合征 痛泻要方 脑源性神经营养因子 5-羟色胺 酪神经肽 炎症因子
|Clinical Study on Tongxie Yaofang for Diarrhea-Type Irritable Bowel Syndrome
|ZHOU Xinghui,ZHENG Yao,TANG Yuxia,LIN Genyou,XIA Yuhong
|Abstract：Objective：To observe the clinical effect of Tongxie Yaofang for diarrhea- type irritable bowel syndrome(IBS).
Methods：A total of 80 patients with diarrhea-type IBS were selected and divided into the control group and the observation
group according to the random number table method， 40 cases in each group. Both groups were given routine
guidance on diet and lifestyle；the control group was additionally given pivecuronium bromide tablets and the observation
group was additionally given Tongxie Yaofang. The clinical effect ， the levels of brain-derived neurotrophic factor(BDNF) ，
5- hydroxytryptamine(5- HT)， neuropeptide(NPY)， interleukin- 8(IL- 8)， interleukin- 10(IL- 10) and interferon- γ(IFN- γ) in
serum in the two groups were detected. Results：The total effective rate was 97.50% in the observation group，higher than
that of 85.00% in the control group，the difference being significant(P＜0.05). After treatment，the times of abdominal pain，
the times of diarrhea，the times of bowl movement and the scores of stool traits and symptoms were all decreased in the two
groups when compared with those before treatment，and the above indexes in the observation group were lower than those
in the control group(P＜0.05). After treatment，the levels of BDNF and NPY in serum in both groups were increased when
compared with those before treatment， and 5- HT levels were decreased(P＜0.05)； the levels of BDNF and NPY in the
observation group were higher than that in the control group，5-HT level was lower than that in the control group(P＜0.05).
After treatment，the levels of IL-8 and IFN-γ in both groups were lower than those before treatment，and the two levels in
the observation group were lower than those in the control group(P＜0.05). The IL-10 levels in the two groups were increased
when compared with those before treatment，and the IL-10 level in the observation group was higher than that in the control
group(P＜0.05). Conclusion： Tongxie Yaofang can effectively relieve the clinical symptoms of diarrhea- type IBS， maintain
the level of BDNF in serum，and inhibit the inflammatory responses.
|Key words: Keywords：Diarrhea-type irritable bowel syndrome Tongxie Yaofang Brain-derived neurotrophic factor 5-hydroxytryptamine Neuropeptide Inflammatory cytokines