| 摘要: |
| 目的：观察导痰汤合身痛逐瘀汤加减联合来那度胺/地塞米松（RD） 方案治疗多发性骨髓瘤（MM） 的临床疗效。方法：将60 例MM 痰瘀痹阻证患者随机分为观察组和对照组各30 例。2 组均以来那度胺胶囊、醋酸地塞米松片治疗，观察组同期采用导痰汤合身痛逐瘀汤加减内服，治疗2 个疗程。于首次化疗后60 d 评估疗效，治疗前后以疼痛视觉模拟法（VAS） 评价骨痛程度，评定Karnofsky 功能状态（KPS） 评分，应用美国国立癌症研究所的化疗药物不良反应（NCI-CTC AE） 记录系统评价不良反应发生情况。比较2 组的临床疗效。结果：治疗后，观察组临床疗效优于对照组（P＜0.05）。2 组骨痛VAS 评分、KPS 评分均较治疗前下降（P＜0.01）。观察组骨痛VAS 评分低于对照组（P＜0.01），KPS 评分高于对照组（P＜0.01）。观察组胃肠道反应、血液学毒性的发生率均低于对照组（P＜0.05），周围神经病变、皮疹和背痛的发生率组间比较，差异均无统计学意义（P＞0.05）。结论：导痰汤合身痛逐瘀汤加减联合RD 方案治疗MM 痰瘀痹阻证患者，可更为有效地减轻疼痛症状，提高患者的生活质量，减轻化疗的不良反应，提高临床治疗效果。 |
| 关键词: 多发性骨髓瘤 痰瘀痹阻证 导痰汤 身痛逐瘀汤 不良反应 |
| DOI： |
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| 基金项目: |
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| Clinical Study on Modified Daotan Tang and Shentong Zhuyu Tang Combined withRoutine Chemotherapy Regimen for Multiple Myeloma |
| YE Xizhong |
| (单篇PDF全文查阅请上中国知网下载阅读（中国知网电子版刊出时间：纸刊刊出日期一个月左右）) |
| Abstract: |
| Abstract： Objective： To observe the clinical effect of modified Daotan tang and Shentong zhuyu tang combined with
lenalidomide/dexamethasone(RD) regimen for multiple myeloma(MM). Methods： A total of 60 cases of MM patients with
phlegm-stasis-obstructing arthralgia syndrome were randomly divided into the observation group and the control group，30
cases in each group. Both groups were given lenalidomide capsules and dexamethasone tablets，and the observation group
was additionally given oral administration of modified Daotan tang and Shentong zhuyu tang at the same period. Both groups
were treated for two courses. The curative effect was evaluated on the 60th day after the first chemotherapy. Before and after
treatment， the degree of bone pain was evaluated by Visual Analogue Scale(VAS)； the score of Karnofsky Performancec
Status(KPS) was evaluated； the incidence of adverse reactions was recorded and evaluated systematically via the National
Cancer Institute Common Toxicity Criteria for Adverse Event(NCI- CTC AE). The clinical effect in the two groups was
compared. Results：After treatment，the clinical effect in the observation group was better than that in the control group(P＜
0.05). The scores of VAS of bone pain and KPS in the two groups were decreased when compared with those before treatment
(P＜0.01). The VAS score of bone pain in the observation group was lower than that in the control group(P＜0.01)，and the
KPS score was higher(P＜0.01). The incidences of gastrointestinal reactions and hematological toxicity in the observation
group were lower than those in the control group(P＜0.05)；when compared the incidence of peripheral neuropathy，rash and
back pain between the two groups，there was no significance in differences among the two groups(P＞0.05). Conclusion：As
for the treatment of MM patients with phlegm-stasis-obstructing arthralgia syndrome，the therapy of modified Daotan tang
and Shentong zhuyu tang combined with RD regimen can more effectively relieve pain， reduce the adverse reactions of
chemotherapy，and improve life quality and clinical effect. |
| Key words: Keywords：Multiple myeloma Phlegm- stasis- obstructing arthralgia syndrome Daotan tang Shentong zhuyu tang Adverse reactions |
