| 摘要: |
| 目的：观察调心安神针法联合常规西药治疗心律失常的疗效。方法：选取158 例心律失常患者，随机分为试验组和对照组各79 例。对照组采取常规西药治疗，试验组在对照组基础上采取调心安神针法治疗，2 组均治疗2 周。观察2 组疗效，比较治疗前、治疗2 周后心功能指标［左室射血分数（LVEF）、左室舒张末期内径（LVEDD）］、心率变异性指标［高频功率（HF）、低频功率（LF）、全程相邻窦性心搏间期之差的均方根（RMSSD）、每5 分钟窦性心搏间期平均值的标准差（SDANN）］、细胞凋亡指标（C-myc、Bcl-2 蛋白），随访6 个月，比较2 组复发率及世界卫生组织生活质量简表（WHOQOL-BREF） 评分。结果：试验组总有效率为94.94%，高于对照组的83.54% （P＜0.05）。治疗2 周后，2 组LVEF、HF、LF、RMSSD、SDANN Bcl-2 水平较治疗前提高，且试验组LVEF、HF、LF、RMSSD、SDANN、Bcl-2 水平高于对照组；2 组LVEDD、C-myc 水平较治疗前降低，且试验组LVEDD、C-myc 水平低于对照组（P＜0.05）。治疗后6 个月，2 组WHOQOL-BREF 评分较治疗前提高，且试验组WHOQOL-BREF 评分高于对照组（P＜0.05）。随访6 个月，试验组复发率为2.67% （2/75），对照组复发率为15.15%（10/66），组间比较，差异有统计学意义（P＜0.05）。结论：调心安神针法联合常规西药治疗心律失常可显著提升疗效，改善患者的心功能及心率变异性，提高C-myc、Bcl-2 蛋白表达，抑制细胞凋亡，提升生活质量，降低复发率。 |
| 关键词: 心律失常 调心安神针法 细胞凋亡 心功能 心率变异性 C-myc Bcl-2 |
| DOI： |
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| 基金项目: |
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| Clinical Study on Tiaoxin Anshen Needling Method Combined with Routine WesternMedicine for Arrhythmia |
| TAO Weijing,YIN Jianquan |
| (单篇PDF全文查阅请上中国知网下载阅读（中国知网电子版刊出时间：纸刊刊出日期一个月左右）) |
| Abstract: |
| Abstract：Objective：To observe the curative effect of Tiaoxin Anshen needling method combined with routine western
medicine for arrhythmia. Methods：A total of 158 cases of patients with arrhythmia were selected and randomly divided into
the experiment group and the control group，79 cases in each group. The control group was given routine western medicine，
and the experiment group was given Tiaoxin Anshen needling method based on the treatment of the control group. Both
groups were treated for two weeks. The curative effect in the two groups was observed；the heart function indexes including
left ventricular ejection fraction(LVEF) and left ventricular end- diastolic diameter(LVEDD) ， the indexes of the heart
rate variability such as high frequency power(HF)， low frequency power(LF)， the root mean square of the successive
differences of sinus inter-beat interval(RMSSD)，and the standard deviation of the averages of normal-to-normal inter-beat
interval of sinus in all 5-minute segments(SDANN)，as well as apoptosis indexes including C-myc and Bcl- 2 protein in the
two groups before treatment were compared with those after two- week treatment. During the six- month follow- up，the
recurrence rate and scores of the World Health Organization Quality of Life Assessment-Brief Version(WHOQOL-BREF) were
compared between the two groups. Results：The total effective rate was 94.94% in the experiment group，higher than that
of 83.54% in the control group(P＜0.05). After two-week treatment，LVEF，HF，LF，RMSSD and SDANN，as well as Bcl-
2 levels in the two groups were increased when compared with those before treatment，and the five indexes and the level in
the experiment group were higher than those in the control group； LVEDD and C- myc levels in the two groups were
decreased when compared with those before treatment，and the index and the level in the experiment group were lower than
those in the control group(P＜0.05). In the six month after treatment，the scores of WHOQOL-BREF in the two groups were increased when compared with those before treatment，and the score in the experiment group was higher than that in the
control group(P＜0.05). During the six-month follow-up，the recurrence rate was 2.67%(2/75) in the experiment group and
15.15% (10/66) in the control group， the difference being significant among the two groups(P＜0.05). Conclusion： The
application of Tiaoxin Anshen needling method combine with routine western medicine in treating arrhythmia， can
significantly promote curative effect and quality of life，improve the heart function and the heart rate variability，increase the
protein expression of C-myc and Bcl-2，and inhibit apoptosis，as well as reduce the recurrence rate. |
| Key words: Keywords： Arrhythmia Tiaoxin Anshen needling method Apoptosis The heart function The heart rate variability C-myc Bcl-2 |
