健脾通窍方治疗慢性分泌性中耳炎临床研究
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R764.21

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Clinical Study on Jianpi Tongqiao Prescription for Chronic Secretory Otitis Media
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    摘要:

    目的:观察健脾通窍方治疗慢性分泌性中耳炎(CSOM) 的临床疗效及对听觉功能的影响。方法:将CSOM 患者94 例随机分为对照组和观察组各47 例,对照组于内镜下经咽鼓管给予地塞米松注射治疗,观察组在对照组的基础上联合健脾通窍方治疗。观察2 组治疗前后中医证候积分、不同频率(1 kHz、2 kHz、4 kHz、8 kHz) 骨导阈值、血清水通道蛋白1(AQP-1)与水通道蛋白4(AQP-4) 水平,并比较2 组临床疗效与复发率。结果:总有效率观察组为87.23%,对照组为70.21%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组患者耳闭、面色无华、便溏等中医证候积分均低于同组治疗前(P<0.05),且观察组各项评分均低于对照组(P<0.05)。治疗后,2 组患者1 kHz、2 kHz、4 kHz、8 kHz 骨导阈值均较治疗前降低(P<0.05),且观察组上述各项指标均低于对照组(P<0.05)。治疗后,2 组患者AQP-1、AQP-4 水平均高于同组治疗前(P<0.05),且观察组两项指标水平均高于对照组(P<0.05)。复发率观察组为12.20%,对照组为45.45%,2 组比较,差异有统计学意义(P<0.05)。结论:地塞米松注射联合健脾通窍方治疗CSOM 疗效优于单纯西药治疗,可显著减轻患者临床症状,改善其骨导阈值及血清AQP-1、AQP-4 水平,降低临床复发率。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Jianpi Tongqiao prescription for chronic secretory otitis media (CSOM) and its effect on auditory function. Methods:A total of 94 cases of CSOM patients were randomly divided into the control group and the observation group, 47 cases in each group. The control group was given the injection of dexamethasone through eustachian tube under endoscope,and the observation group was additionally given Jianpi Tongqiao prescription based on the treatment of the control group. The Chinese medicine syndrome scores, the thresholds of bone conduction at various frequencies including 1 kHz, 2 kHz, 4 kHz and 8 kHz, and the levels of aquaporin- 1(AQP- 1) and aquaporin- 4(AQP- 4) in serum before and after treatment were observed in the two groups; the clinical effect and the recurrence rate were compared between the two groups. Results: The total effective rate was 87.23% in the observation group and 70.21% in the control group, the difference being significant(P<0.05). After treatment, the Chinese medicine syndrome scores including deafness and lusterless complexion as well as thin and unformed stool in the two groups were lower than those in the same group before treatment(P<0.05),and each score in the observation group was lower than that in the control group(P<0.05). After treatment,the thresholds of bone conduction at 1 kHz,2 kHz,4 kHz and 8kHz in the two groups were decreased when compared with those before treatment(P<0.05), and the above each index in the observation group was lower than that in the control group(P<0.05). After treatment,the levels of AQP-1 and AQP-4 in the two groups were higher than those in the same group before treatment(P<0.05),and the two levels in the observation group were higher than those in the control group(P<0.05). The recurrence rate was 12.20% in the observation group and 45.45% in the control group, the difference being significant(P<0.05). Conclusion: The injection of dexamethasone combined with Jianpi Tongqiao prescription has better curative effect than that of simple western medicine in treating CSOM, which can significantly alleviate patients' clinical symptoms,improve their thresholds of bone conduction and levels of AQP-1 and AQP- 4 in serum,as well as reduce clinical recurrence rate.

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刘莹,魏炯洲,徐建友.健脾通窍方治疗慢性分泌性中耳炎临床研究[J].新中医,2020,52(15):82-85

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  • 在线发布日期: 2020-08-08
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