Abstract： Objective： To systematically evaluate the curative effect of Yangxin Tongmai method for coronary heart disease. Methods： All the relevant literature about Yangxin Tongmai method treating coronary heart disease from the establishment date of the database to March 1， 2020 was detected in PubMed， Cochrane library， Medline、Embase， CNKI， VIP， Wangfang and CBM. The enrolled literature was given quality evaluation and information extraction. Metaanalysis and trial sequential analysis were carried out by RevMan5.3 software and TSAv0.9 software respectively. Results： There were 17 literature included. According to the Meta- analysis result： the improvement of angina pectoris in the observation group was better than that in the control group(RR=1.22， 95% CI[1.17， 1.28]， Z=8.21， P＜0.000 01)； the improvement of electrocardiogram in the observation group was better than that in the control group(RR=1.30，95%CI[1.22， 1.40]，Z=7.49，P＜0.000 01)；the improvement of clinical symptoms in the observation group was better than that in the control group(RR=1.31， 95% CI[1.12， 1.52]， Z=3.46， P=0.000 5). The trial sequential analysis showed that the Metaanalysis got a false positive result. Conclusion： The curative effect of Yangxin Tongmai method in treating coronary heart disease needs to be further proved by more rigorous randomized controlled trials.