| 摘要: |
| 目的：观察桃红四物汤对气阴两虚兼血瘀型糖尿病足患者微炎症状态、足部血流的改善作用。方法：选取气阴两虚兼血瘀型糖尿病足患者118例，按随机数字表法分为对照组和观察组各59例。对照组采用常规治疗，观察组在对照组基础上采用桃红四物汤治疗。观察2组炎症因子、足背动脉内径及血流变化、全血黏度、中医证候积分和临床疗效。结果：观察组总有效率为91.53%，高于对照组72.88%，差异有统计学意义（P＜0.05）。治疗后，2组白细胞介素-6（IL-6）、白细胞介素-12（IL-12）、肿瘤坏死因子-α （TNF-α）、高敏C-反应蛋白（hs-CRP） 水平较治疗前降低（P＜0.05），且观察组IL-6、IL-12、TNF-α、hs-CRP水平低于对照组（P＜0.05）。治疗后，2组左右足背动脉内径、左右两侧血流速度均较治疗前升高（P＜0.05），且观察组左右足背动脉内径、左右两侧血流速度高于对照组（P＜0.05）。治疗后，观察组低切变率下全血黏度较治疗前降低，且低于对照组，差异均有统计学意义（P＜0.05）。治疗后，观察组面色无华，神疲乏力、少气懒言，腰疼，浮肿，肌肤甲错，麻木各项评分均显著低于对照组（P＜0.05）。结论：桃红四物汤对气阴两虚兼血瘀型糖尿病足患者炎症因子有显著的清除作用，有效改善患者微炎症状态，并促进足部血流和增加足部血管内径，改善糖尿病足患者足部内环境。 |
| 关键词: 糖尿病足 气阴两虚 血瘀 桃红四物汤 炎症因子 足部血流 全血黏度 中医证候积分 |
| DOI： |
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| 基金项目:河南省2014年基础与前沿技术研究计划项目（142300410221） |
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| Clinical Study on Taohong Siwu Tang for Diabetic Foot of Qi-Yin Deficiency Com⁃bined with Blood Stasis Type |
| ZHU Yongzhi,CAO Peiqian,XU Jinping |
| (单篇PDF全文查阅请上中国知网下载阅读（中国知网电子版刊出时间：纸刊刊出日期一个月左右）) |
| Abstract: |
| Abstract：Objective：To observe the effect of Taohong Siwu tang on the improvement of micro-inflammatory state and
pedal blood flow in patients with diabetic foot of qi-yin deficiency combined with blood stasis type. Methods：A total of 118
cases of patients with diabetic foot of qi- yin deficiency combined with blood stasis type were selected and divided into the
control group and the observation group according to the random number table method，59 cases in each group. The control
group was given routine treatment， and the observation group was additionally given Taohong Siwu tang based on the
treatment of the control group. The changes in inflammatory factors， the inner diameter of dorsalis pedis artery and blood
flow， the whole blood viscosity， the Chinese medicine syndrome scores and the clinical effect in the two groups were
observed. Results：The total effective rate was 91.53% in the observation group，higher than that of 72.88% in the control
group，the difference being significant(P＜0.05). After treatment，the levels of interleukin- 6(IL-6)，interleukin- 12(IL-12)，
tumor necrosis factor- α(TNF- α) and high- sensitivity C- reactive protein(hs- CRP) in the two groups were decreased when
compared with those before treatment(P＜0.05)，and the above levels in the observation group were lower than those in the
control group(P＜0.05). After treatment，in both left and right sides，inner diameter of dorsalis pedis artery and blood flow
velocity in the two groups were increased when compared with those before treatment(P＜0.05)，and the inner diameter and
velocity in the observation group were higher than those in the control group(P＜0.05). After treatment， the whole blood
viscosity at low shear rate in the observation group was decreased when compared with that before treatment，and lower
than that in the control group，differences being significant(P＜0.05). After treatment，each score of lusterless complexion，
lack of mental vigor and physical strength， weak breathing and laziness to speak， pain in waist， edema， as well as
squamous and dry skin and numbness in the observation group was significantly lower than that in the control group(P＜0.05). Conclusion： The therapy of Taohong Siwu tang has significant scavenging effect on inflammatory factors in patients with
diabetic foot of qi-yin deficiency combined with blood stasis type. It can effectively improve their micro-inflammatory state，
promote pedal blood flow and increase the inner diameter of pedal blood vessel，as well as improve their internal environment
of the foot. |
| Key words: Keywords： Diabetic foot Qi- yin deficiency Blood stasis Taohong Siwu tang Inflammatory factors Pedal blood
vessel Whole blood viscosity Chinese medicine syndrome scores |
