补肾活血汤加减联合枸橼酸氯米芬胶囊治疗肾虚血瘀型多囊卵巢综合征所致不孕症临床研究
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R711.6;R711.75

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Clinical Study on Modified Bushen Huoxue Tang Combined with Clomifene Citrate Capsules for Infertility Caused by Polycystic Ovary Syndrome of Kidney Deficiency and Blood Stasis Type
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    摘要:

    目的:观察补肾活血汤加减联合枸橼酸氯米芬胶囊治疗多囊卵巢综合征(PCOS) 所致不孕症的临床疗效。方法:选取80 例肾虚血瘀型PCOS 所致不孕症患者,按随机数字表法分为对照组与观察组各40 例。对照组给予枸橼酸氯米芬胶囊治疗,观察组给予补肾活血汤加减联合枸橼酸氯米芬胶囊治疗,2 组均连续治疗3 个月经周期。比较2 组治疗前后血清抗苗勒管激素(AMH)、雌二醇(E2)、睾酮(T) 水平及卵泡发育情况、中医证候评分,对比2组临床疗效。结果:治疗后,2组血清E2、T及AMH水平均较治疗前降低(P<0.05),观察组血清E2、T及AMH水平均低于对照组(P<0.05)。治疗后,2组卵泡数目均较治疗前减少(P<0.05),优势卵泡最大直径均较治疗前增大(P<0.05),中医证候评分均较治疗前降低(P<0.05);观察组卵泡数目少于对照组(P<0.05),优势卵泡最大直径大于对照组(P<0.05),中医证候评分低于对照组(P<0.05)。观察组总有效率90.00%,对照组总有效率72.50%,2组比较,差异有统计学意义(P<0.05)。结论:补肾活血汤加减联合枸橼酸氯米芬胶囊治疗肾虚血瘀型PCOS所致不孕症,可以改善患者的性激素水平,促进卵泡生长发育和卵巢储备功能恢复。

    Abstract:

    Abstract: Objective: To observe the clinical effect of modified Bushen Huoxue tang combined with clomifene citrate capsules for infertility caused by polycystic ovary syndrome(PCOS). Methods:A total of 80 cases of patients with infertility caused by PCOS of the kidney deficiency and blood stasis type were selected and divided into the control group and the observation group according to the random number table method,40 cases in each group. The control group was treated with clomifene citrate capsules,and the observation group was additionally treated with modified Bushen Huoxue tang based on the treatment in the control group. Both groups were continuously treated for three menstrual cycles. The levels of antimullerian hormone(AMH),estradiol(E2) and testosterone(T) in serum,the growth of follicles and Chinese medicine syndrome scores before and after treatment were compared between the two groups. The clinical effect in the two groups was compared. Results: After treatment, the levels of E2, T and AMH in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of above three index in the observation group were all lower than those in the control group(P<0.05). After treatment, when compared with those before treatment, the number of follicles in the two groups were decreased(P<0.05), the maximum diameter of dominant follicle increased(P<0.05), and Chinese medicine syndrome scores decreased(P<0.05). After treatment,compared with those in the control group,in the observation group, the number of follicles was less(P<0.05), the maximum diameter of dominant follicle was larger(P< 0.05), the Chinese medicine syndrome scores was lower(P<0.05). The total effective rate was 90.00% in the observation group,and 72.50% in the control group,differences being significant(P<0.05). Conclusion:The therapy of Bushen Huoxue tang combined with clomifene citrate capsules in treating infertility caused by PCOS of the kidney deficiency and blood stasis type, which can improve the levels of sex hormones and conduce to the growth of follicles and the recovery of ovarian reserve function.

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张小文.补肾活血汤加减联合枸橼酸氯米芬胶囊治疗肾虚血瘀型多囊卵巢综合征所致不孕症临床研究[J].新中医,2020,52(13):46-48

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  • 在线发布日期: 2020-07-10
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