| 摘要: |
| 目的：观察凉血解毒重镇汤治疗寻常型银屑病血热证的疗效及对患者免疫功能、生活质量、T淋巴细胞亚群及炎症因子水平的影响。方法：选取80例寻常型银屑病血热证患者，随机分为治疗组和对照组各40例，对照组给予消银颗粒口服联合卡泊三醇软膏外涂治疗，治疗组在对照组基础上给予凉血解毒重镇汤治疗。比较2组总有效率，观察治疗前后银屑病皮损面积与严重程度指数（PASI）、皮肤病生活质量指数量表（DLQI）、CD4+、CD8+、CD4+/CD8+及肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-6、IL-23 的变化情况。结果：治疗组总有效率92.50%，高于对照组的75.00%，差异有统计学意义（χ2=4.248，P＜0.05）。治疗后，2组PASI 评分与DLQI 评分均较治疗前降低（P＜0.05），治疗组PASI 评分与DLQI 评分均低于对照组（P＜0.05）。治疗后，2组CD4+、CD4+/CD8+水平均较治疗前升高（P＜0.05），治疗组CD4+、CD4+/CD8+水平均高于对照组（P＜0.05）；2组CD8+水平均较治疗前降低，治疗组CD8+水平低于对照组（P＜0.05）。治疗后，2 组TNF-α、IL-6、IL-23 水平均较治疗前降低（P＜0.05），治疗组TNF-α、IL-6、IL-23水平均低于对照组（P＜0.05）。结论：凉血解毒重镇汤可以提高免疫功能，减轻炎症反应，从而有效改善寻常型银屑病血热证患者的皮损程度，提高其生活质量。 |
| 关键词: 寻常型银屑病 血热证 凉血解毒重镇汤 银屑病皮损面积与严重程度指数 皮肤病生活质量指数量表 T淋巴细胞亚群 炎症因子 |
| DOI： |
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| 基金项目: |
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| Clinical Study on Liangxue Jiedu Zhongzhen Tang for Psoriasis Vulgaris with Blood Heat Syndrome |
| WANG Gang,LI Jianwei |
| (单篇PDF全文查阅请上中国知网下载阅读（中国知网电子版刊出时间：纸刊刊出日期一个月左右）) |
| Abstract: |
| Abstract：Objective：To observe the curative effect of Liangxue Jiedu Zhongzhen tang for psoriasis vulgaris with blood heat syndrome，and its effect on immune function，quality of life，and the levels of T lymphocyte subsets and inflammatory factors. Methods： A total of 80 cases of patients with psoriasis vulgaris with blood heat syndrome were selected and randomly divided into the treatment group and the control group，40 cases in each group.The control group was given oral administration of Xiaoyin granules combined with external application of calcipotriol ointment，and the treatment group was additionally treated with Liangxue Jiedu Zhongzhen tang based on the treatment in the control group. After treatment， the total clinical effective rate was compared between the two groups. The changes in the Psoriasis Area and Severity Index (PASI)，Dermatology Life Quality Index(DLQI)，CD4+，CD8+，CD4+/CD8+，tumor necrosis factor-α(TNF-α)，interleukin(IL)-6 and IL-23 before and after treatment were observed. Results：The total effective rate was 92.50% in the treatment group，higher than that of 75.00% in the control group，the difference being significant(χ 2=4.248，P＜0.05). After treatment，the scores of PASI and DLQI in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above two scores in the treatment group were lower than those in the control group(P＜0.05). After treatment，the levels of CD4+ and CD4+/CD8+ in the two groups were increased when compared with those before treatment(P＜0.05)；the levels of CD4+ and CD4+/CD8+ in the treatment group were higher than those in the control group(P＜0.05)；the levels of CD8+ in the two grops were decreased when compared with those before treatment(P＜0.05)，and the level in the treatment group was lower than that in the control group(P＜0.05). After treatment，the levels of TNF-α，IL-6 and IL-23 in the two groups were decreased when compared with those before treatment(P＜0.05)， and the levels in the treatment group were lower than those in the control group(P＜0.05). Conclusion：Liangxue Jiedu Zhongzhen tang can improve immune function and alleviate inflammatory responses，thus it is effective to decrease the severity of skin lesions and improve the quality of life for patients with psoriasis vulgaris with blood heat syndrome. |
| Key words: Keywords： Psoriasis vulgaris Blood heat syndrome Liangxue Jiedu zhongzhen tang Psoriasis Area and Severity Index Dermatology Life Quality Index T lymphocyte subsets Inflammatory factors |
