附桂骨痛胶囊治疗类风湿关节炎临床研究
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R593.22

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Clinical Study on Fugui Gutong Capsules for Rheumatoid Arthritis
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    摘要:

    目的:观察附桂骨痛胶囊治疗类风湿关节炎的临床疗效。方法:将124例类风湿关节炎患者随机分为观察组与对照组,各62例。对照组给予类风湿关节炎的常规治疗,即以甲氨蝶呤为主要药物。观察组则服用附桂骨痛胶囊,比较2种治疗方法的临床疗效,同时评估血清白细胞介素-1 (IL-1)、白细胞介素-6 (IL-6)、肿瘤坏死因子-α (TNF-α)、红细胞沉降率(ESR) 和C-反应蛋白(CRP) 水平治疗前后的变化。结果:治疗后,对照组总有效率为64.51%,观察组总有效率为87.10%,2组比较,差异有统计学意义(P<0.05)。2组治疗前的晨僵时间、关节肿胀疼痛比较,差异无统计学意义(P>0.05);治疗后,2组临床症状与治疗前比较均有减轻、缓解好转(P<0.05);且观察组治疗后临床症状比对照组治疗后效果更显著(P<0.05)。2组治疗前ESR、CRP、IL-1、IL-6、TNF-α比较,差异无统计学意义(P>0.05);治疗后2组均较前显著下降,观察组治疗后炎症因子较对照组下降更显著(P<0.05)。观察组发生3 例不良反应,对照组发生9 例不良反应,差异无统计学意义(P>0.05)。结论:附桂骨痛胶囊对类风湿关节炎有较好的疗效,能进一步改善患者临床症状,降低体内炎性水平,有助于患者康复。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Fugui Gutong capsules for rheumatoid arthritis. Methods:A total of 124 patients with rheumatoid arthritis were randomly divided into the observation group and the control group,62 cases in each group. The control group was given conventional treatment, namely, methotrexate as the main medicine; the observation group was treated with Fugui Gutong capsules. The clinical effect in the two groups was compared,and changes in the levels of interleukin- 1(IL- 1),interleukin- 6(IL- 6),tumor necrosis factor- α(TNF- α),erythrocyte sedimentation rate (ESR) and C-reactive protein(CRP) in serum before and after treatment were evaluated. Results:After treatment,the total effective rate was 64.51% in the control group and 87.10% in the observation group, the difference being significant(P<0.05). There was no significant difference in the comparison of morning stiffness time, joint swelling and pain before treatment between the two groups(P>0.05). After treatment,the clinical symptoms in the two groups were alleviated and improved when compared with those before treatment(P<0.05),and the clinical symptoms in the observation group were improved more significantly than those in the control group(P<0.05). There was no significant difference in the comparison of the levels of ESR,CRP,IL-1,IL-6 and TNF-α between the two groups before treatment(P>0.05). After treatment,the levels of inflammatory cytokines in the observation group were decreased more significantly when compared with those in the control group(P<0.05). Three cases of adverse reactions occurred in the observation group and nine cases in the control group,there being no significant difference(P>0.05). Conclusion:Fugui Gutong capsules has significant therapeutic effect in treating rheumatoid arthritis, which can further improve the clinical symptoms, reduce the inflammatory levels, and is conducive to the rehabilitation of patients.

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章森桥,朱弢,施建辉.附桂骨痛胶囊治疗类风湿关节炎临床研究[J].新中医,2020,52(12):60-63

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  • 在线发布日期: 2020-06-15
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