Abstract： Objective： To observe the clinical effect of Bushen Zhuangjin tang combined with acupuncture and moxibustion for lumbar disc herniation of liver- kidney depletion type and its effect on the expression of nucleotide- binding oligomerization domain- like receptor protein 3(NLRP3) inflammasomes in peripheral blood mononuclear cells. Methods： A total of 96 cases of patients were randomly divided into the control group and the observation group，48 cases in each group.The control group was given routine traction therapy，and the observation group was additionally given Bushen Zhuangjin tang combined with acupuncture and moxibustion. The clinical effect，the expression of NLRP3 inflammasomes，interleukin-1β (IL-1β) and interleukin-1(IL-6)，the scores of Japanese Orthopaedic Association(JOA) and incidence of adverse reactions in the two groups were observed and compared. Results： The total effective rate was 95.83% in the observation group and 77.08% in the control group，the difference being significant(P＜0.05). After treatment，the levels of ASC mRNA in the two groups were lower than those before treatment(P＜0.05)，and the levels of Caspase-1 mRNA and NLRP3 mRNA were higher than those before treatment(P＜0.05)；the improvement of the indexes above in the observation group was more significant than that in the control group(P＜0.05). After treatment， the levels of IL- 1β and IL- 6 in the two groups were lower than those before treatment(P＜0.05)，and the levels of IL- 1β and IL- 6 in the observation group were lower than those in the control group(P＜0.05). After treatment， the scores of JOA in the two groups were significantly higher than those before treatment(P＜0.05)， and the scores of JOA in the observation group were higher than those in the control group(P＜0.05). There were 2 cases of hematoma and 1 case of local and intense stabbing pain in acupuncture area in the control group，which were improved via symptomatic treatment. Conclusion： The therapy of Bushen Zhuangjin tang combined with acupuncture and moxibustion has significant curative effect in treating lumbar disc herniation of liver-kidney depletion type，which can effectively inhibit inflammatory response of body，thus improving the clinical symptoms of patients.