| 摘要: |
| 目的：观察逍遥散联合氨甲环酸射频导入治疗黄褐斑的临床疗效。方法：将130 例黄褐斑患者按随机数字表法分为观察组和对照组各65 例。对照组给予氨甲环酸射频导入治疗，观察组在对照组基础上给予逍遥散加减口服。比较2 组临床疗效及治疗前后黄褐斑面积和严重指数（MASI） 评分、中医证候评分，检测血清丙二醛（MDA）、晚期氧化蛋白产物（AOPP）、谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD） 含量，比较2 组皮肤屏障功能指标角质层含水量、经皮失水值（TEWL）和黑色素指数。结果：观察组总有效率为90.77%，高于对照组84.62%，差异有统计学意义（P＜0.05）。治疗前，2 组MASI 评分及中医证候评分比较，差异无统计学意义（P＞0.05）。治疗后，2 组MASI 评分及中医证候评分较治疗前降低，且观察组MASI评分及中医证候评分低于对照组，差异均有统计学意义（P＜0.05）。治疗前，2 组血清MDA、AOPP、GSH-Px、SOD 含量比较，差异均无统计学意义（P＞0.05）。治疗后，2 组血清MDA、AOPP 含量较治疗前降低，GSH-Px、SOD 含量较治疗前升高；且观察组血清MDA、AOPP 含量低于对照组，GSH-Px、SOD 含量高于对照组；差异均有统计学意义（P＜0.05）。治疗前，2 组角质层含水率、TEWL 值及黑色素指数比较，差异无统计学意义（P＞0.05）。治疗后，2 组角质层含水率较治疗前升高，TEWL 值、皮肤黑色素指数较治疗前下降，观察组上述指标改善情况均优于对照组，差异均有统计学意义（P＜0.05）。结论：逍遥散联合氨甲环酸射频导入有利于改善黄褐斑患者的氧化应激状态，促进皮肤屏障功能的修复，缓解症状，治疗黄褐斑效果确切。 |
| 关键词: 黄褐斑 逍遥散 氨甲环酸射频导入 氧化应激 皮肤屏障功能 |
| DOI： |
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| 基金项目: |
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| Clinical Study on Xiaoyao Powder Combined with Radio Frequency Importing TranexamicAcid for Chloasma |
| ZHOU Lin |
| (单篇PDF全文查阅请上中国知网下载阅读（中国知网电子版刊出时间：纸刊刊出日期一个月左右）) |
| Abstract: |
| Abstract： Objective： To observe the clinical effect of Xiaoyao powder combined with radio frequency importing
tranexamic acid for chloasma. Methods： A total of 130 cases of patients with chloasma were divided into the observation
group and the control group according to the random number table method，65 cases in each group. The control group was
given radio frequency importing tranexamic acid，and the observation group was additionally given the oral administration of
modified Xiaoyao powder based on the treatment of the control group. The clinical effect was compared between the two
groups， as well as the area of chloasma， scores of Melasma Area Severity Index(MASI) and Chinese medicine syndrome
scores before and after treatment. The contents of malondialdehyde(MDA)， advanced oxidation protein products(AOPP)，
glutathione peroxidase(GSH- Px) and superoxide dismutase(SOD) in serum were detected. The indexes of the skin barrier
function，namely，water content in stratum corneum，transepidermal water loss(TEWL) and melanin index were compared
between the two groups. Results：The total effective rate was 90.77% in the observation group，higher than that of 84.62%
in the control group， the difference being significant(P＜0.05). Before treatment， when compared the MASI scores and
Chinese medicine syndrome scores between the two groups， there was no significance in the difference(P＞0.05). After
treatment，the MASI scores and Chinese medicine syndrome scores in the two groups were decreased when compared with
those before treatment，and the two scores in the observation group were lower than those in the control group，differences
being significant(P＜0.05). Before treatment， when compared the contents of MDA， AOPP， GSH- Px and SOD in serum
between the two groups， there was no significance in differences(P＞0.05). After treatment， the contents of MDA and
AOPP in serum in the two groups were decreased when compared with those before treatment， and the contents of
GSH-Px and SOD were increased；the contents of MDA and AOPP in serum in the observation group were lower than those
in the control group， and the contents of GSH- Px and SOD were higher， differences being significant(P＜0.05). Before
treatment，when compared the water ratio in stratum corneum，TEWL value and melanin index between the two groups，
there was no significance in the difference(P＞0.05). After treatment，the water ratios in stratum corneum in the two groups
were increased when compared with those before treatment， and TEWL values and the skin melanin indexes were
decreased；the improvement of the above three indexes in the observation group was better than that in the control group，
differences being significant(P＜0.05). Conclusion：The therapy of Xiaoyao powder combined with radio frequency importing
tranexamic acid conduces to improving oxidative stress status in patients with chloasma，promoting the recovery of the skin
barrier function，and relieving symptoms，with defined curative effect in treating chloasma. |
| Key words: Keywords： Chloasma Xiaoyao powder Radio frequency importing tranexamic acid Oxidative stress Skin barrier
function |
