Abstract： Objective： To observe the clinical effect of Xiaoyao powder combined with radio frequency importing tranexamic acid for chloasma. Methods： A total of 130 cases of patients with chloasma were divided into the observation group and the control group according to the random number table method，65 cases in each group. The control group was given radio frequency importing tranexamic acid，and the observation group was additionally given the oral administration of modified Xiaoyao powder based on the treatment of the control group. The clinical effect was compared between the two groups， as well as the area of chloasma， scores of Melasma Area Severity Index(MASI) and Chinese medicine syndrome scores before and after treatment. The contents of malondialdehyde(MDA)， advanced oxidation protein products(AOPP)， glutathione peroxidase(GSH- Px) and superoxide dismutase(SOD) in serum were detected. The indexes of the skin barrier function，namely，water content in stratum corneum，transepidermal water loss(TEWL) and melanin index were compared between the two groups. Results：The total effective rate was 90.77% in the observation group，higher than that of 84.62% in the control group， the difference being significant(P＜0.05). Before treatment， when compared the MASI scores and Chinese medicine syndrome scores between the two groups， there was no significance in the difference(P＞0.05). After treatment，the MASI scores and Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment，and the two scores in the observation group were lower than those in the control group，differences being significant(P＜0.05). Before treatment， when compared the contents of MDA， AOPP， GSH- Px and SOD in serum between the two groups， there was no significance in differences(P＞0.05). After treatment， the contents of MDA and AOPP in serum in the two groups were decreased when compared with those before treatment， and the contents of GSH-Px and SOD were increased；the contents of MDA and AOPP in serum in the observation group were lower than those in the control group， and the contents of GSH- Px and SOD were higher， differences being significant(P＜0.05). Before treatment，when compared the water ratio in stratum corneum，TEWL value and melanin index between the two groups， there was no significance in the difference(P＞0.05). After treatment，the water ratios in stratum corneum in the two groups were increased when compared with those before treatment， and TEWL values and the skin melanin indexes were decreased；the improvement of the above three indexes in the observation group was better than that in the control group， differences being significant(P＜0.05). Conclusion：The therapy of Xiaoyao powder combined with radio frequency importing tranexamic acid conduces to improving oxidative stress status in patients with chloasma，promoting the recovery of the skin barrier function，and relieving symptoms，with defined curative effect in treating chloasma.