| 摘要: |
| 目的：探讨复方斑蝥胶囊辅助化疗对老年晚期非小细胞肺癌患者的疗效以及对血清生存素（Survivin） 和胸苷激酶1水平的影响。方法：将60例晚期非小细胞肺癌老年患者按数字表法随机分为对照组和观察组各30例。对照组按规范给予TP方案。观察组在对照组基础上采取复方斑蝥胶囊治疗，连续治疗6周。比较2组临床疗效、T淋巴细胞亚群变化、血清Survivin和胸苷激酶1水平。结果：观察组近期总有效率为66.67%，显著高于对照组43.33%（P＜0.05）。观察组治疗后CD3+、CD3+/CD4+显著升高且明显多于对照组，CD3+/CD8+显著降低且明显低于对照组（P＜0.01）。对照组治疗前后CD3+、CD3+/CD4+、CD3+/CD8+治疗前后变化不明显（P＞0.05）。2 组治疗后血清Survivin、胸苷激酶1 水平降低（P＜0.01）；且观察组治疗后血清Survivin、胸苷激酶1水平低于对照组（P＜0.01）。结论：复方斑蝥胶囊辅助化疗可增强晚期非小细胞肺癌老年患者的免疫功能，提高临床疗效，且可抑制血清Survivin和胸苷激酶1水平。 |
| 关键词: 非小细胞肺癌 老年 复方斑蝥胶囊 免疫功能 胸苷激酶1 血清生存素 |
| DOI： |
|
| 基金项目: |
|
| Clinical Study on Compound Banmao Capsules Assisting Chemotherapy for Advanced Non-small Cell Lung Cancer in Senile Patients |
| YAN Mengyuan,YE Zuorong |
| (单篇PDF全文查阅请上中国知网下载阅读（中国知网电子版刊出时间：纸刊刊出日期一个月左右）) |
| Abstract: |
| Abstract：Objective：To discuss the curative effect of compound Banmao capsules assisting chemotherapy for advanced non-small cell lung cancer in senile patients and its effect on levels of survivin and thymidine kinase 1 in serum. Methods：A total of 60 cases of senile patients with advanced non- small cell lung cancer were divided into the control group and the observation group according to the random number table method，30 cases in each group. The control group was routinely given TP regimen， and the observation group was additionally treated with compound Banmao capsules based on the treatment of the control group. Both groups were treated for six weeks. The clinical effect，the changes of T- lymphocyte
subsets and the levels of survivin and thymidine kinase 1 in serum in the two groups were compared. Results：The recent total effective rate was 66.67% in the observation group， significantly higher than that of 43.33% in the control group(P＜0.05). After treatment， CD3 + and CD3 +/CD4 + in the observation group were significantly increased， and were significantly higher than those in the control group；CD3+/CD8+ was significantly decreased，and was significantly lower than that in the control group(P＜0.01). Before and after treatment，compared CD3+，CD3+/CD4+ and CD3+/CD8+，there was no significant difference being found in the control group(P＞0.05). After treatment，the levels of survivin and thymidine kinase 1 in serum in the two groups were decreased(P＜0.01)； the above levels in the observation group were lower than those in the control
group(P＜0.01). Conclusion：Compound Banmao capsules assisting chemotherapy can improve immune function and clinical effect in senile patients with advanced non-small cell lung cancer，and inhibit the levels of survivin and thymidine kinase 1 in serum. |
| Key words: Keywords：Non-small cell lung cancer Senile Compound Banmao capsules Immune function Thymidine kinase 1 Survivin in serum |
