麝香保心丸治疗老年冠心病患者PCI 术后临床研究
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Clinical Study on Heart-protecting Musk Pills for Senile Patients with Coronary Heart Disease after PCI
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    摘要:

    目的:观察麝香保心丸对老年冠心病患者经皮冠状动脉介入(PCI) 术后的影响。方法:将因冠心病进行PCI治疗的82例老年患者,随机分为对照组和治疗组,每组41例;2组均择期行PCI治疗,对照组术后常规给予阿司匹林、氯吡格雷、瑞舒伐他汀抗凝降脂治疗,治疗组在对照组的基础上加用麝香保心丸治疗;观察比较2组治疗前后细胞黏附因子-1(VCAM-1)、细胞间黏附因子-1(ICAM-1)、超敏C-反应蛋白(hs-CRP) 的变化,2组血流动力学(全血黏度、血浆黏度、纤维蛋白原) 指标变化;观察比较2 组总体临床疗效。结果:总有效率治疗组为92.7%,对照组为78.0%,2 组比较,差异有统计学意义(P<0.05)。治疗后2 组VCAM-1、ICAM-1、hs-CRP 水平均较治疗前显著下降(P<0.05),且治疗组各项指标均明显低于对照组(P<0.05)。治疗后2组全血黏度、血浆黏度、纤维蛋白原水平均较治疗前显著下降(P<0.05),且治疗组各项指标均明显低于对照组(P<0.05)。结论:在常规西药治疗的基础上,加用麝香保心丸治疗PCI术后老年冠心病患者疗效显著,可有效改善患者术后炎症反应及血液流变学状态,值得临床推广应用。

    Abstract:

    Abstract:Objective:To observe the effect of heart-protecting musk pills on senile patients with coronary heart disease after percutaneous coronary intervention(PCI). Methods: A total of 82 cases of senile patients after PCI for coronary heart disease were randomly divided into the control group and the treatment group,41 cases in each group. Both groups were treated with PCI at selected time. After operation, the control groupwasroutinely given aspirin, clopidogrel and rosuvastatin for anticoagulant and lipid- lowering treatment, and the treatment group was additionally treated withheartprotecting musk pills. The changes of vascular cell adhesion molecule-1(VCAM-1),intercellular adhesion molecule-1(ICAM-1),hypersensitive C-reactive protein(hs-CRP) and hemodynamic indexes including the whole blood viscosity,plasma viscosity and fibrinogen before and after treatment, and the total clinical effect in the two groups were observed and compared.Results: The total effective rate was 92.7% in the treatment group and 78.0% in the control group, the difference being significant(P<0.05). After treatment, the levels of VCAM- 1, ICAM- 1 and hs- CRP in the two groups were significantly decreased when compared with those before treatment(P<0.05), and the above levels in the treatment group were significantly lower than those in the control group(P<0.05). After treatment,the levels of the whole blood viscosity,plasma viscosity and fibrinogen in the two groups were significantly decreased when compared with those before treatment(P<0.05), and the above levels in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion: Based on routine western medicine treatment, the additional application ofheart- protecting musk pills has significant curative effect in treating senile patients with coronary heart disease after PCI,which can effectively improve the postoperative inflammatory reactions and the hemodynamic state of patients,and it is worthy of clinical promotion.

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朱赟,陈子茵,李海英,王微.麝香保心丸治疗老年冠心病患者PCI 术后临床研究[J].新中医,2020,52(10):40-42

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  • 在线发布日期: 2020-05-26
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