| 摘要: |
| 目的：探讨养血活血安胎法治疗血栓前状态复发性流产的临床效果。方法：选取血栓前状态复发性流产孕妇86例，按随机数字表法分为研究组和对照组各43例。对照组应用常规西药治疗，研究组在对照组基础上应用养血活血安胎法治疗。比较2 组临床疗效，检测凝血指标、纤溶指标及子宫动脉血流阻力值变化。结果：研究组总有效率为90.7%，高于对照组79.1%（P＜0.05）。治疗前，2组凝血指标凝血酶原时间（PT）、凝血酶时间（TT）、活化部分凝血活酶时间（APTT） 水平比较，差异无统计学意义（P＞0.05）。治疗后，2组PT、TT较治疗前降低，APTT较治疗前升高；且研究组PT低于对照组，差异均有统计学意义（P＜0.05）。治疗前，2组纤溶指标抗凝血酶Ⅲ（AT-Ⅲ）、D-二聚体（D-D）、纤维蛋白原（FIB） 水平比较，差异无统计学意义（P＞0.05）。治疗后，2组AT-Ⅲ水平较治疗前升高，D-D、FIB水平较治疗前降低；且研究组AT-Ⅲ水平高于对照组，D-D、FIB水平低于对照组；差异均有统计学意义（P＜0.05）。治疗前，2组左侧RI值、右侧RI值以及双侧S/D之和比较，差异无统计学意义（P＞0.05）。治疗后，2组左侧RI值、右侧RI值以及双侧S/D之和较治疗前降低，且研究组左侧RI值、右侧RI值以及双侧S/D之和均低于对照组；差异均有统计学意义（P＜0.05）。结论：针对血栓前状态复发性流产的治疗，采用养血活血安胎法可以有效改善孕妇凝血、纤溶状态，提高治疗有效率，改善妊娠结局，临床上值得应用。 |
| 关键词: 复发性流产 血栓前状态 养血活血安胎法 凝血指标 纤溶指标 妊娠结局 |
| DOI： |
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| Clinical Study on Yangxue Huoxue Antai Method for Pre- thrombotic State of Recur⁃rent Spontaneous Abortion |
| GAO Tao |
| () |
| Abstract: |
| Abstract： Objective： To discuss the clinical effect of Yangxue Huoxue Antai method for pre- thrombotic state of
recurrent spontaneous abortion. Methods：A total of 86 cases of patients with pre-thrombotic state of recurrent spontaneous
abortion were divided into the study group and the control group according to the random number table method，43 cases in
each group. The control group was given routine western medicine， and the study group was additionally treated with
Yangxue Huoxue Antai method based on the treatment of the control group. The clinical effect in the two groups was
compared. The changes in coagulation indexes，fibrinolytic parameters and uterine arterial resistance values were detected.
Results： The total effective rate was 90.7% in the study group， higher than that of 79.1% in the control group(P＜0.05).
Before treatment， compared the levels of coagulation indexes including prothrombin time(PT)， thrombin time(TT) and
activated partial thromboplastin time(APTT) in the two groups， there was no significance in the difference(P＞0.05). After
treatment，the levels of PT and TT in the two groups were decreased when compared with those before treatment，and the
levels of APTT were increased；the level of PT in the study group was lower than that in the control group，differences being
significant(P＜0.05). Before treatment，compared the levels of fibrinolytic parameters including antithrombin Ⅲ(AT-Ⅲ)，Ddimer(
D-D)，fibrinogen(FIB) between the two groups，there was no significance in the difference(P＞0.05). After treatment，
the levels of AT-Ⅲ in the two groups were increased when compared with those before treatment，and the levels of D-D
and FIB were decreased；the level of AT-Ⅲ in the study group was higher than that in the control group，and the levels of
D-D and FIB were lower than those in the control group ； differences being significant(P ＜ 0.05). Before treatment ，
compared the left RI value， right RI value， and the sum of bilateral S/D values between the two groups， there was no
significance in the difference(P＞0.05). After treatment，the left RI value，right RI value，and the sum of bilateral S/D values
in the two groups were decreased when compared with those before treatment，and the above values in the study group
were all lower than those in the control group；differences being significant(P＜0.05). Conclusion：In the treatment of prethrombotic
state of recurrent spontaneous abortion， the Yangxue Huoxue Antai method can effectively relieve coagulation
and fibrinolysis of pregnant women，enhance the cure effective rate，and improve pregnancy outcome，which is worthy of
clinical application. |
| Key words: Keywords ： Recurrent spontaneous abortion Pre- thrombotic state Yangxue Huoxue Antai method Coagulation
indexes Fibrinolytic parameters Pregnancy outcome |
