健脾消积清热法防治大肠腺瘤息肉复发临床研究
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R574.6

基金项目:

国家自然科学基金项目(86266890)


Clinical Study on Jianpi Xiaoji Qingre Method in Preventing and Treating Recurrence of Colorectal Adenomatous Polyps
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:观察健脾消积清热法对大肠腺瘤息肉复发的防治效果及其对血清特异性生长因子(TSGF)、糖类抗原199(CA199) 及表皮生长因子受体(EGFR) 表达的影响。方法:选择86 例符合纳入标准的患者作为研究对象,随机分为2 组各43 例。所有患者均行电子内镜下腺瘤性肠息肉切除,对照组术后除常规治疗外不给予其他治疗,观察者于术后第2天起给予健脾消积清热汤内服治疗。结果:观察组中医证候疗效显著高于对照组,差异有统计学意义(P<0.05)。2组中医证候积分均比治疗前显著降低,且观察组明显低于对照组,差异均有统计学意义(P<0.05)。观察组6个月复发率显著低于对照组,差异有统计学意义(P<0.05)。治疗后,2 组血清TSGF、CA199、表皮细胞生长因子(EGF)、EGFR 含量均有明显降低,差异有统计学意义(P<0.05),且观察组显著低于对照组,差异有统计学意义(P<0.05)。结论:健脾消积清热汤治疗大肠腺瘤息肉临床症状改善明显,能显著降低大肠腺瘤息肉复发率,可能与抑制血清TSGF、CA199及表皮生长因子受体的表达有关。

    Abstract:

    Abstract: Objective: To observe the effect of Jianpi Xiaoji Qingre method on preventing and treating recurrence of colorectal adenomatous polyps, and on the expression of tumor specific growth factor(TSGF), carbohydrate antigen 199 (CA199) and epidermal growth factor receptor(EGFR) in serum. Methods: A total of 86 cases of patients who met the inclusive criteria were selected as study objects,and randomly divided into two groups,43 cases in each group. All patients were given the incision of adenomatous intestinal polyps via electronic endoscope;the control group was only given routine treatment;the observation group was given the oral administration of Jianpi Xiaoji Qingre tang since the 2nd day after surgery. Results:The curative effect of Chinese medicine syndromes in the observation group was significantly better than that in the control group, the difference being significant(P<0.05). Chinese medicine syndrome scores in the two groups were significantly decreased when compared with those before treatment; the Chinese medicine syndrome score in the observation group was significantly lower than that in the control group;differences were significant(P<0.05). The recurrence rate in six months in the observation group was significantly lower than that in the control group, the difference being significant(P<0.05). After treatment, the contents of TSGF, CA199, epidermal growth factor(EGF) and EGFR in serum in the two groups were significantly decreased,the difference being significant(P<0.05);the indexes above in the observation group were significantly lower than those in the control group; differences were significant(P<0.05). Conclusion: Jianpi Xiaoji Qingre method can significantly improve the clinical symptoms in treating colorectal adenomatous polyps,and reduce the recurrence rate of colorectal adenomatous polyps,which may relate to the inhibition of the expression of TSGF,CA199 and epidermal growth factor receptor in serum.

    参考文献
    相似文献
    引证文献
引用本文

郭海军,郭秀霞,王本贤.健脾消积清热法防治大肠腺瘤息肉复发临床研究[J].新中医,2020,52(9):66-69

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2020-05-09
  • 出版日期: