醒脑静注射液对急性缺血性脑卒中患者 神经功能恢复的影响及抗炎作用研究
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R743.33

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A Study of Effect of Xingnaojing Injection on Recovery of Neurological Function in Patients with Acute Ischemic Stroke and Its Anti-inflammatory Effect
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    摘要:

    目的:观察醒脑静注射液对急性缺血性脑卒中患者神经功能恢复的影响及对炎症因子的作用。方法:将100例急性缺血性脑卒中痰热内闭证患者随机分为对照组和观察组各50例。对照组予辛伐他汀片、阿司匹林肠溶片、依达拉奉注射液,并给予防治感染,降颅压,维持水、电解质平衡,支持及控制血压等综合处理措施。观察组在对照组治疗的基础上给予醒脑静注射液。疗程均为14 d。于治疗前和治疗7 d、14 d评价美国国立卫生研究院脑卒中量表(NIHSS) 评分、日常生活活动能力(ADL)评分和痰热内闭证评分,检测血清同型半胱氨酸(Hcy)、肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6) 和超敏C-反应蛋白(hs-CRP) 水平。比较2组的临床疗效。结果:治疗后,观察组临床疗效优于对照组(P<0.05)。2组痰热内闭证评分均较治疗前下降,ADL评分均较治疗前升高,差异均有统计学意义(P<0.01)。观察组痰热内闭证评分低于对照组(P<0.01),ADL评分高于对照组(P<0.01)。2 组血清Hcy、IL-6、TNF-α 和hs-CRP 水平与治疗前比较均下降(P<0.01);观察组4 项指标水平均低于对照组(P<0.01)。治疗7 d、14 d,2组NIHSS评分均较治疗前下降(P<0.05);观察组治疗7 d、14 d的NIHSS评分均低于同期对照组(P<0.05)。结论:在现代医学常规疗法的基础上加用醒脑静注射液干预急性缺血性脑卒中患者,能进一步改善神经功能,减轻临床症状,提高患者的日常生活活动能力,其作用可能与减轻炎症反应、改善脑损伤有关,值得临床进一步研究。

    Abstract:

    Abstract:Objective:To observe the effect of Xingnaojing injection on recovery of neurological function in patients with acute ischemic stroke and its effect on inflammatory factors. Methods:A total of 100 cases of patients with acute ischemic stroke with syndrome of internal block of phlegm- heat were randomly divided into the control group and the observation group,50 cases in each group. The control group was treated with simvastatin tablets,aspirin enteric- coated tablets and edaravone injection, and given comprehensive treatment measures including preventing and treating infection, lowering intracranial pressure, maintaining water and electrolyte balance and supporting and controlling blood pressure. The observation group was additionally treated with Xingnaojing injection based on the treatment of the control group. Both groups were treated for 14 days. Before treatment and after treatment for 7 and 14 days respectively, the scores of National Institutes of Health Stroke Scale(NIHSS),Activities of Daily Living(ADL) and Chinese medicine syndromes were evaluated, and the levels of homocysteine(Hcy),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and high-sensitivity C-reactive protein(hs-CRP) in serum were detected. The clinical effect in the two groups was compared. Results:After treatment,the clinical effect in the observation group was better than that in the control group(P<0.05). The Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment, and the ADL scores were increased,differences being significant(P<0.01). The Chinese medicine syndrome score in the observation group was lower than that in the control group(P<0.01),and the ADL score was higher than that in the control group(P<0.01). The levels of Hcy,IL-6,TNF-α and hs-CRP in serum in the two groups were decreased when compared with those before treatment (P<0.01); the above four levels in the observation group were all lower than those in the control group(P<0.01). After treatment for 7 and 14 days, the NIHSS scores in the two groups were decreased when compared with those before treatment(P<0.05);the NIHSS scores in the two different time points in the observation group were both lower than those in the control group at the same time point(P<0.05). Conclusion:Based on routine therapy of modern medicine,the additional application of Xingnaojing injection in treating patient with acute ischemic stroke can effectively relieve clinical symptoms and improve neurological function and activities of daily living. Its effect may be related to the alleviation of inflammatory reactions and the improvement of brain injury,which is worthy of further clinical study.

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吴勤烽,徐利芬.醒脑静注射液对急性缺血性脑卒中患者 神经功能恢复的影响及抗炎作用研究[J].新中医,2020,52(9):52-55

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  • 在线发布日期: 2020-05-09
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