Abstract：Objective：To observe the clinical effect of modified Lichong tang combined with paclitaxel and carboplatin(TC) regimen for advanced ovarian cancer， and its effect on hemorheological indexes， the immune function and the levels of tumor markers. Methods：A total of 96 cases of patients with advanced ovarian cancer were divided into the control group and the observation group according to the random number table method，48 cases in each group. The control group was treated with TC regimen，and the observation group was additionally treated with modified Lichong tang based on the treatment of the control group. Both groups were treated for two courses， 21 days being a course. The Chinese medicine syndrome scores before and after treatment and the incidence of adverse reactions during treatment in the two groups were counted； the levels of hemorheological indexes，T cell subsets and tumor markers were detected；the clinical effect was compared between the two groups. Results： After treatment， the scores of masses in the lower abdomen， distending pain of abdomen，dim complexion，and emaciation in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above four Chinese medicine syndrome scores in the observation group were lower than those in the control group(P＜0.05). The disease control rate was 77.08% in the observation group， higher than that of 56.25% in the control group(P＜0.05). The effective rate was 54.17% in the observation group， and 41.67% in the control group， there being no significance in the difference(P＞0.05). After treatment，the levels of hemorheological indexes including whole blood viscosity of high shear，middle shear and low shear，as well as plasma viscosity in the two groups were decreased when compared with those before treatment(P＜0.05)，the above four levels in the observation group were lower than those in the control group(P＜0.05). After treatment，the levels of CD8+ were decreased(P＜0.05)；the levels of CD3+，CD4+ and CD4+/ CD8 + in the observation group were higher than those in the control group(P＜0.05)，and the level of CD8 + was lower(P＜ 0.05). After treatment，the contents of carbohydrate antigen 125(CA125)，carbohydrate antigen 19- 9(CA19- 9) and alphafetoprotein( AFP) in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above three contents in the observation group were lower than those in the control group(P＜0.05). The incidence of leukopenia was 6.25% in the observation group， lower than that of 27.08% in the control group(P＜0.05). Compared the incidence of anemia， thrombocytopenia， nausea and vomiting， and diarrhea， there being no significance in the difference(P＞0.05). Conclusion： The therapy of modified Lichong tang combined with TC regimen in treating advanced ovarian cancer can effectively improve the clinical symptoms，hemorheological indexes and the immune function，and reduce the level of tumor markers and adverse reactions induced by chemotherapy.