Abstract： Objective： To observe the clinical effect of exercise for health preservation of Chinese medicine combined with routine nursing in intervening type 2 diabetes mellitus. Methods： A total of 89 cases of patients with type 2 diabetes mellitus were divided into the control group and the observation group according to the random number table method，44 and 45 cases in each group respectively. The control group was given routine treatment and nursing intervention， and the observation group was additionally given exercise for health preservation of Chinese medicine based on the treatment of the control group. The changes of blood pressure，blood glucose including fasting blood glucose(FBG) and 2h post-meal glucose (P2hBG)， fasting insulin(FINS)， insulin resistance index(HOMA- IR)， body mass index(BMI) and 25- hydroxyvitamin D(25- OHD) before and after nursing，as well as the time for blood glucose to return to normal and satisfaction scores after nursing in the two groups were observed and compared. Results： After intervention， the levels of systolic pressure， diastolic pressure，FPG and 2hPG in the observation group were obviously lower than those in the control group，the difference being significant(P＜0.05). After intervention，the levels of FINS and HOMA-IR in the observation group were obviously lower than those in the control group，and the level of 25-OHD was obviously higher than that in the control group，differences being significant(P＜0.05). After intervention，the BMI and the time for blood glucose to return to normal in the observation group were obviously less than those in the control group，and the satisfaction score was obviously higher than that in the control group， differences being significant(P＜0.05). Conclusion： Based on the routine treatment， the therapy of exercise for health preservation of Chinese medicine combined with routine nursing can effectively improve blood glucose， blood pressure and insulin resistance，the levels of indexes of bone metabolism and the satisfaction scores，and shorten the time for blood glucose to return to normal.