Abstract： Objective： To observe the clinical effect of Peitu Huazheng tang combined with antivirus for patients with hepatitis B(HB for short) in decompensated cirrhosis. Methods： Divided 102 cases of patients with HB in decompensated cirrhosis into the antivirus group and the combination group randomly，51 cases in each group. The antivirus group received routine antiviral therapy with entecavir，while the combination group additionally received Peitu Huazheng tang.The course of treatment in both groups lasted for 6 months. Observed and compared the changes of therapeutic effect，Chinese medicine syndrome scores， indexes of hepatic fibrosis [hyaluronic acid(HA)， laminin(LN)， pro- collagen type IIIN- terminal peptide (PIIINP)，type C pro-collagen-IV(Col-IV)]，indexes of liver function[alanine aminotransferase(ALT)，aspartate aminotransferase (AST)， albumin(Alb)， total bilirubin(TBil)]， and the quantification of hepatitis B virus- deoxyribonucleic acid(HBV- DNA)， transient elastic imaging(Fibroscan)of liver and B-ultrasonic imaging examination in liver，and observed adverse reactions in both groups. Results： The total effective rate was 82.35% in the combination group and 64.71% in the antivirus group， difference being significant(P＜0.05). After treatment， Chinese medicine syndrome scores ofless food intake and poor appetite， distending pain in chest and hypochondrium， dim complexion， gastric fullness， lassitude and fatigue in both groups were lower than those before treatment，and each score above in the combination group was obviously lower than that in the antivirus group(P＜0.05). After treatment，the levels of HA，LN，PIIINP and Col-Ⅳin both groups were lower than those before treatment(P＜0.05)， and each score above in the combination group was obviously lower than that in the antivirus group(P＜0.05). After treatment，the levels of ALT，AST and TBil and quantification of HBV-DNA were lower than those before treatment(P＜0.05)，and the level of Alb was higher than that before treatment(P＜0.05)；each score above in the combination group was improved more significant than those in the control group(P＜0.05). The rate of virological response was 80.39% in the combination group and 60.78% in the antivirus group， difference being significant(P＜0.05). After treatment， the width of portal vein， thickness of spleen， length of spleen， and liver stiffness in Fibroscan in both groups were lower than those before treatment，and each index above in the combination group was obviously lower than that in the antivirus group(P＜0.05). The incidence of adverse reactions was 7.84% in the combination group and 9.80% in the antivirus group，difference being insignificant(P＞0.05). Conclusion：The application of Peitu Huazheng tang combined with antivirus has definite overall therapeutic effect in treating HB in decompensated cirrhosis. It can relieve Chinese medicine syndrome，improve liver function and alleviate hepatic cirrhosis.